The UALCAN and GEPIA Analyses of the TCGA Database Show a Strong Association Between Increased Expression of Stathmin 1 in Adrenocortical Carcinoma Tissues and Patient Survival.
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Abstract
Background/aim: Adrenocortical carcinoma (ACC) arises from the adrenal cortex. This cancer is characterized by a very low incidence, poor prognosis and high mortality rate. Because early detection is extremely difficult and no effective treatment has been established, the five-year survival rate is very low. Therefore, there is an urgent need to identify biomarkers and therapeutic target molecules that can serve as early detection and prognostic factors. Stathmin 1 is a ubiquitously expressed 19 kDa cytosolic phosphoprotein, which induces microtubule depolymerization and regulates microtubule-dependent processes such as cell division and motility. Its over-expression has been linked to cell migration and invasion in sarcoma, malignant glioma, gastric cancer, colorectal cancer, and non-small cell lung cancer. However, the clinicopathological involvement of stathmin 1 in ACC, has not yet been reported.
Materials and methods: The GEPIA and UALCAN platforms were used to analyze stathmin 1 mRNA expression and its association with survival in patients with ACC using TCGA data.
Results: TCGA analysis showed that the expression of stathmin 1 was significantly increased in ACC tissues, and patients with increased expression of stathmin 1 in cancer tissues had a significantly shorter survival time.
Conclusion: Stathmin 1 is highly expressed in ACC tissues and inversely correlated with patient prognosis, suggesting it may be a potential prognostic biomarker for patients with ACC. Furthermore, the GEPIA and UALCAN platforms proved to be highly effective in investigating the correlation between the expression levels of stathmin 1 in ACC tissues and the survival time of patients using the TCGA database.
期刊介绍：
ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed.
ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies).
Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.
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