Mechanisms of lung crosstalk with end organs: scientific session V-ReSPIRE 2025.

IF 3.5 2区 医学 Q1 PHYSIOLOGY
Navneet Singh, Ceren Koçana, Eric P Schmidt, Mark L Hepokoski, Michael A Matthay, Troy Stevens
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引用次数: 0

Abstract

Session V of the inaugural biennial Research Symposium on Pulmonary Injury and Repair of the Endothelium showcased cutting-edge research on pulmonary endothelial crosstalk with end organs and its role in vascular disease. Growing evidence suggests that communication between injured organs and distal vascular beds plays a critical role in the pathogenesis of complex conditions such as sepsis, acute respiratory distress syndrome, pulmonary arterial hypertension, and heart failure with preserved ejection fraction. Circulating mediators-including heparan sulfate fragments, proinflammatory cytokines, mitochondrial damage-associated molecular patterns, bone morphogenetic protein 9, bile acids, and nitric oxide-have emerged as key factors linking pulmonary endothelial dysfunction to neural impairment, acute kidney injury, subclinical liver injury, and left-sided heart disease. This review highlights recent advances in the field, identifies critical knowledge gaps, and outlines future research directions aimed at elucidating mechanisms of multiorgan dysfunction and identifying novel therapeutic targets.

肺与末端器官串扰的机制:科学会议V:呼吸2025。
首届肺内皮损伤和修复研究研讨会(ReSPIRE)第五部分展示了与终末器官的肺内皮串扰及其在血管疾病中的作用的前沿研究。越来越多的证据表明,受伤器官和远端血管床之间的交流在脓毒症、急性呼吸窘迫综合征、肺动脉高压和保留射血分数的心力衰竭等复杂疾病的发病机制中起着关键作用。循环介质——包括硫酸肝素片段、促炎细胞因子、线粒体损伤相关分子模式、骨形态发生蛋白9、胆汁酸和一氧化氮——已成为连接肺内皮功能障碍与神经损伤、急性肾损伤、亚临床肝损伤和左侧心脏病的关键因素。本文综述了该领域的最新进展,确定了关键的知识空白,并概述了未来的研究方向,旨在阐明多器官功能障碍的机制和确定新的治疗靶点。
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来源期刊
CiteScore
9.20
自引率
4.10%
发文量
146
审稿时长
2 months
期刊介绍: The American Journal of Physiology-Lung Cellular and Molecular Physiology publishes original research covering the broad scope of molecular, cellular, and integrative aspects of normal and abnormal function of cells and components of the respiratory system. Areas of interest include conducting airways, pulmonary circulation, lung endothelial and epithelial cells, the pleura, neuroendocrine and immunologic cells in the lung, neural cells involved in control of breathing, and cells of the diaphragm and thoracic muscles. The processes to be covered in the Journal include gas-exchange, metabolic control at the cellular level, intracellular signaling, gene expression, genomics, macromolecules and their turnover, cell-cell and cell-matrix interactions, cell motility, secretory mechanisms, membrane function, surfactant, matrix components, mucus and lining materials, lung defenses, macrophage function, transport of salt, water and protein, development and differentiation of the respiratory system, and response to the environment.
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