Circulating Interleukin-6 Levels and Timing of Acute Ischemic Stroke Onset

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2025-07-22 DOI:10.1002/acn3.70138

Robert G. Kowalski, Aurélie Ledreux, John E. Violette, Whitney Paustian, Stefan Sillau, John A. Thompson, Robert T. Neumann, David Ornelas, Andrew A. Monte, Layne Dylla, Adit A. Ginde, Andra M. Farcas, Christina M. Coughlan, William J. Jones, James C. Grotta, Michael W. Graner

引用次数: 0

Abstract

Intravenous thrombolysis is the most widely available effective ischemic stroke treatment, but is approved only if given within 4.5 h from stroke onset. Many patients are not treated because stroke onset time is unknown. We evaluated the cytokine interleukin 6 (IL-6) in circulating blood after acute ischemic stroke (AIS). Results show IL-6 is elevated as early as 26 min after stroke and increases over 24 h. The IL-6 levels can estimate when the stroke occurred with 80% sensitivity and 74% specificity. With refinement, a point-of-care blood test for IL-6 during stroke could substantially increase the number of stroke patients eligible for thrombolysis.

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循环白细胞介素-6水平与急性缺血性卒中发病时间的关系。

静脉溶栓是最广泛使用的有效的缺血性卒中治疗方法，但只有在卒中发作后4.5小时内给予静脉溶栓才被批准。许多患者没有得到治疗，因为中风发作时间不明。我们评估了急性缺血性卒中（AIS）后循环血液中细胞因子白细胞介素6 （IL-6）的变化。结果显示，IL-6在脑卒中后26min升高，24h后升高。IL-6水平能以80%的敏感性和74%的特异性判断脑卒中发生的时间。随着改进，中风期间的即时血液检测IL-6可以大大增加适合溶栓治疗的中风患者数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.