Identification of Dementia With Lewy Bodies by Skin Biopsy in Recent-Onset Cognitive Impairment

IF 3.9 2区 医学 Q1 CLINICAL NEUROLOGY
Alessandro Furia, Alex Incensi, Cecilia Delprete, Giovanni Rizzo, Salvatore Bonvegna, Marco Piatti, Enrica Olivola, Francesco Ventruto, Veria Vacchiano, Enrico Fileccia, Roberto Cilia, Nicola Modugno, Rocco Liguori, Vincenzo Donadio
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引用次数: 0

Abstract

Immunofluorescence for phosphorylated alpha-synuclein in skin biopsy samples is an emerging biomarker in synucleinopathies comprising Dementia with Lewy bodies. In this pilot study, 19 patients with recent-onset (≤ 18 months) cognitive impairment underwent skin biopsy at baseline, with follow-up clinical re-evaluation. Five patients fulfilled the Dementia with Lewy bodies diagnosis, all of them positive for skin phosphorylated alpha-synuclein. The remaining 14 patients were all negative. Skin tissue immunofluorescence may represent a promising technique in identifying synuclein pathology in recent-onset cognitive decline: larger cohorts are needed to confirm our preliminary data.

Abstract Image

Abstract Image

新发认知障碍患者皮肤活检诊断路易体痴呆
皮肤活检样本中磷酸化α -突触核蛋白的免疫荧光检测是包括路易体痴呆在内的突触核蛋白病的新兴生物标志物。在这项初步研究中,19例新近发病(≤18个月)的认知障碍患者在基线时接受了皮肤活检,并进行了随访的临床再评估。5例患者符合路易体痴呆诊断,均为皮肤磷酸化α -突触核蛋白阳性。其余14例均为阴性。皮肤组织免疫荧光可能代表了一种很有前途的技术,用于识别近期发病的认知衰退的突触核蛋白病理:需要更大的队列来证实我们的初步数据。
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来源期刊
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)
CiteScore
9.10
自引率
1.90%
发文量
218
审稿时长
8 weeks
期刊介绍: Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.
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