A Systems Biology Perspective on Childhood ADHD: Neurochemical Dysregulation, Brain-Behavior Interactions, and Emerging Therapeutics

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

The FASEB Journal Pub Date : 2025-09-04 DOI:10.1096/fj.202501829RR

Norah Suliman Alsoqih, Elsayed A. Elmorsy, Rasha Abu-Khudir, Sameh Saber, Noha Keshk, Fatma Elnaghy, Rabab S. Hamad, Attalla F. El-kott, Sally Negm, Mohammed A. AlShehri, Mohamed A. M. Ali, Mustafa Ahmed Abdel-Reheim, Alshaimaa A. Farrag, Hanan Eissa, Ahmed Gaafar, Mahmoud E. Youssef

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引用次数: 0

Abstract

Attention deficit hyperactivity disorder (ADHD) is a pervasive neurodevelopmental condition that typically manifests during childhood. Its symptoms manifest much earlier—often before the age of seven. With the disorder's continuous patterns of inattention, hyperactivity, and impulsiveness, it gets in the way of academic, social, and occupational performance. Individuals affected by ADHD are found among all age groups, though its presentation may change over time. The mechanisms of ADHD seem to be very complex and multifactorial and include disturbances within neuroanatomical structures, neurochemical systems, and developmental trajectories. These influences create the characteristic behavior and cognitive profiles of an individual with ADHD that substantiate the heterogeneity of the disorder. This review will be centered on biology and development regarding ADHD, with contributions from modern scientific research. It will also delve into novel pharmacological therapeutic approaches for the management of ADHD.

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儿童多动症的系统生物学观点：神经化学失调、脑-行为相互作用和新兴治疗方法

注意缺陷多动障碍（ADHD）是一种普遍的神经发育疾病，通常表现在儿童时期。它的症状表现得更早——通常在7岁之前。由于这种障碍的持续模式是注意力不集中、多动和冲动，它阻碍了学业、社交和职业表现。受ADHD影响的个体存在于所有年龄组，尽管其表现可能随时间而变化。ADHD的机制似乎是非常复杂和多因素的，包括神经解剖结构、神经化学系统和发育轨迹的紊乱。这些影响创造了ADHD个体的特征行为和认知特征，证实了该疾病的异质性。本文将以ADHD的生物学和发育为中心，并结合现代科学研究的贡献。它还将深入研究新的药物治疗方法来管理多动症。

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来源期刊

The FASEB Journal 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

6243

审稿时长

3 months

期刊介绍： The FASEB Journal publishes international, transdisciplinary research covering all fields of biology at every level of organization: atomic, molecular, cell, tissue, organ, organismic and population. While the journal strives to include research that cuts across the biological sciences, it also considers submissions that lie within one field, but may have implications for other fields as well. The journal seeks to publish basic and translational research, but also welcomes reports of pre-clinical and early clinical research. In addition to research, review, and hypothesis submissions, The FASEB Journal also seeks perspectives, commentaries, book reviews, and similar content related to the life sciences in its Up Front section.