Anna Pacwa, Klaudia Mroz, Xiaonan Liu, Adrian Smedowski
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引用次数: 0
Abstract
Gap junctions are essential channels of communication between cells including neurons in the central nervous system. These channels coordinate cell metabolic and electrical functions including such crucial ones for maintaining homeostasis as cell proliferation, differentiation, survival, and apoptosis. They create narrow passageways that allow rapid exchange of small molecules, ions, and secondary messengers between neighboring cells including the retina and optic nerve. Disruption in normal functioning of gap junctions may result in various neurodegenerative disorders. A comprehensive understanding of gap junction composition, function, and regulation is the key in determining novel approaches to neuroprotection and neuroregeneration. Here, we review the structure and the role of gap junctions in the retina and discuss the life cycle of connexins and their involvement in retinal neurodegenerations.
期刊介绍：
The Journal of Cell Communication and Signaling provides a forum for fundamental and translational research. In particular, it publishes papers discussing intercellular and intracellular signaling pathways that are particularly important to understand how cells interact with each other and with the surrounding environment, and how cellular behavior contributes to pathological states. JCCS encourages the submission of research manuscripts, timely reviews and short commentaries discussing recent publications, key developments and controversies.
Research manuscripts can be published under two different sections :
In the Pathology and Translational Research Section (Section Editor Andrew Leask) , manuscripts report original research dealing with celllular aspects of normal and pathological signaling and communication, with a particular interest in translational research.
In the Molecular Signaling Section (Section Editor Satoshi Kubota) manuscripts report original signaling research performed at molecular levels with a particular interest in the functions of intracellular and membrane components involved in cell signaling.
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