A Journey between Neurons and Astrocytes: A Tribute to Giorgio Carmignoto

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemical Research Pub Date : 2025-09-04 DOI:10.1007/s11064-025-04527-3

Micaela Zonta, Stefano Vicini, Nicoletta Berardi, Lamberto Maffei, Gian Michele Ratto, Paulo J. Magalhães, Tommaso Fellin, Gabriele Losi, Marta Gómez-Gonzalo, Alexei Verkhratsky

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Abstract

The intimate relation between astrocytes and blood vessels was proposed by Camillo Golgi in 1870. Santiago Ramon y Cajal subsequently introduced the idea of astrocytes as regulators of functional hyperaemia accompanying neuronal activity in 1895. In 2003 Giorgio Carmignoto, Micaela Zonta, Tullio Pozzan and their colleagues revealed mechanisms of astrocytic control over vasodilatation. They demonstrated that astrocytic Ca²⁺ signals are fundamental for translating neuronal activity into an increase of arterioles diameter, which in turn results in a local increase in the blood flow. This special issue celebrates the career of Giorgio, by gathering contributions of many friends of him, who will guide us along his scientific journey in this introductory paper, as well as presents original papers and reviews dedicated to astrocytes and their multiple functional role. It will become soon evident to the readers how, in every environment he has worked and lived, Giorgio developed strong relationships with people, always with the strong belief in the crucial role of collaborative effort in science, as well as in the value of friendship in life.

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神经元和星形胶质细胞之间的旅程：致敬乔治·卡米诺托

星形胶质细胞与血管的密切关系是由卡米洛·高尔基于1870年提出的。随后，Santiago Ramon y Cajal在1895年提出了星形胶质细胞作为伴随神经元活动的功能性充血的调节因子的观点。2003年，Giorgio Carmignoto、Micaela Zonta、Tullio Pozzan和他们的同事揭示了星形细胞控制血管舒张的机制。他们证明星形细胞Ca2+信号是将神经元活动转化为小动脉直径增加的基础，小动脉直径增加反过来导致局部血流量增加。这期特刊通过收集他的许多朋友的贡献来庆祝Giorgio的职业生涯，他们将在这篇介绍性的论文中引导我们沿着他的科学之旅，并展示专门研究星形胶质细胞及其多种功能作用的原创论文和评论。读者很快就会明白，在他工作和生活的每一个环境中，乔治是如何与人建立起牢固的关系的，他始终坚信合作在科学中发挥着至关重要的作用，也坚信友谊在生活中的价值。

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.