Natural Killer Cells Are Dispensable for Virus Control in Rag2−/− Mice During Primary RSV Infection

IF 3.7 3区 医学 Q2 IMMUNOLOGY
Joy Nakawesi, Tammie Sow Tao Min, Cecilia Johansson
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引用次数: 0

Abstract

Respiratory syncytial virus (RSV) is one of the major causes of severe lower respiratory tract infections, especially in children, the elderly, and immunocompromised individuals. Complications arising from viral infections in these age groups can present therapeutic challenges, as most of these individuals have impaired adaptive immunity. Using the T- and B cell-deficient Rag2−/− mice, the mechanisms that mediate protection in immunocompromised hosts during RSV infection can be investigated. RSV-infected Rag2−/− mice showed no symptoms of disease or chronic inflammation in the lungs and airways despite the presence of infectious virus in their lungs several months after infection. Interestingly, Natural Killer (NK) cells, the main innate cells with anti-viral cytotoxic effector functions, were recruited 2 days earlier in the lungs of Rag2−/− mice compared with wildtype mice, resulting in early production of IFN-γ. However, depletion of NK cells did not affect disease severity or viral load. Together, these results suggest that the NK cells are largely dispensable for virus control during primary RSV infection in Rag2−/− mice.

Abstract Image

自然杀伤细胞在Rag2−/−小鼠原发RSV感染期间的病毒控制中是必不可少的
呼吸道合胞病毒(RSV)是严重下呼吸道感染的主要原因之一,特别是在儿童、老年人和免疫功能低下的个体中。在这些年龄组中,病毒感染引起的并发症可能给治疗带来挑战,因为这些人中的大多数都有适应性免疫受损。使用T和B细胞缺陷的Rag2 - / -小鼠,可以研究RSV感染期间免疫功能低下宿主介导保护的机制。rsv感染的Rag2 - / -小鼠在感染几个月后肺部存在感染性病毒,但没有表现出疾病症状或肺部和呼吸道的慢性炎症。有趣的是,与野生型小鼠相比,Rag2−/−小鼠的肺中具有抗病毒细胞毒性效应的主要天然细胞NK细胞被提前2天招募,导致IFN-γ的早期产生。然而,NK细胞的消耗并不影响疾病的严重程度或病毒载量。总之,这些结果表明,在Rag2−/−小鼠的原发RSV感染期间,NK细胞在很大程度上是可替代的。
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来源期刊
CiteScore
8.30
自引率
3.70%
发文量
224
审稿时长
2 months
期刊介绍: The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.
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