Baseline Single-Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls

Abstract

Dysregulated cytokine secretion and signaling underlie systemic autoinflammatory diseases (SAIDs). Here, we characterized immune dysregulation in SAID patients by profiling cytokine secretion at the single-cell level, establishing measurements for secretion dynamics and cellular polyfunctionality, compared with healthy controls, revealing natural variability within immune responses between donors.