“Good” fats, bad news: HDL-delivered vitamin E shields tumors from ferroptosis

Abstract

In a recent study published in Nature, Calhoon et al.¹ reported that glycosaminoglycan (GAG)-mediated uptake of lipoproteins protects cancer cells from ferroptosis by delivering α-tocopherol, the most abundant form of vitamin E. This discovery offers potential therapeutic opportunities to either target GAG-dependent lipid uptake or modulate dietary vitamin E to enhance ferroptosis-based cancer therapies.