ESA VIVALDI Dry Immersion Microgravity Simulations Induce Increases in Immune Biomarkers Associated With Physical and Psychological Stress, and Sex-Specific Factors

IF 4.2 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Pauline Jacob, Adrien Robin, Nastassia Navasiolava, Marc-Antoine Custaud, Stéphanie Ghislin, Marie-Pierre Bareille, Rebecca Billette De Villemeur, Inês Antunes, Angelique Van Ombergen, Guillemette Gauquelin-Koch, Jean-Pol Frippiat
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Abstract

With future manned space projects involving missions of unprecedented duration, multisystem deconditioning induced by spaceflight could seriously affect the well-being and health of astronauts. Safe and easily determined in-flight biomarkers are therefore needed to monitor health status. In this study, we simulated space deconditioning with a 5-day dry immersion (DI) of 18 healthy women and 19 healthy men and evaluated the effects of this protocol on three biomarkers: the neutrophil-to-lymphocyte ratio (NLR), the granulocyte-to-lymphocyte ratio (GLR) and the platelet-to-lymphocyte ratio (PLR). Increases in all three ratios were observed in both men and women, as also observed at the end of a space mission or after exposure to simulated microgravity. These increases were associated with physical and psychological stress in both sexes. Furthermore, our work suggested a positive link between NLR increase and cardiovascular system alteration in women, whereas in men, there would be a positive relationship between NLR, GLR, PLR, and inflammation. Thus, in addition to physical and psychological stress, sex-specific factors could contribute to increases in NLR, GLR, and PLR ratios during DI. As for the increase in PLR, it did not predict the development of long-lasting immune diseases during DI, in contrast to 2 months of head-down tilt bed rest (HDBR), another spaceflight analog. These data show that the NLR, GLR, and PLR ratios are promising biomarkers that deserve further study to determine the relationships between their increase and microgravity-induced deconditioning. These dry immersion investigations are registered at clinicaltrials.gov as NCT05043974 for women and NCT05493176 for men.

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ESA VIVALDI干浸泡微重力模拟诱导与生理和心理应激以及性别特异性因素相关的免疫生物标志物的增加
随着未来载人航天工程涉及前所未有的持续时间任务,航天飞行引起的多系统失调可能严重影响宇航员的福祉和健康。因此,需要安全且易于确定的飞行生物标志物来监测健康状况。在这项研究中,我们对18名健康女性和19名健康男性进行了为期5天的干浸泡(DI)模拟空间调节,并评估了该方案对三个生物标志物的影响:中性粒细胞与淋巴细胞比率(NLR)、粒细胞与淋巴细胞比率(GLR)和血小板与淋巴细胞比率(PLR)。在男性和女性中都观察到这三个比率的增加,在太空任务结束或暴露于模拟微重力环境后也观察到这一点。这些增加与男女的生理和心理压力有关。此外,我们的研究表明,NLR增加与女性心血管系统改变之间存在正相关,而在男性中,NLR、GLR、PLR与炎症之间存在正相关。因此,除了生理和心理压力外,性别特异性因素可能导致DI期间NLR、GLR和PLR比率的增加。至于PLR的增加,与2个月的头向下倾斜床休息(HDBR)(另一种航天模拟)相比,它并不能预测DI期间长期免疫疾病的发展。这些数据表明,NLR、GLR和PLR比率是有希望的生物标志物,值得进一步研究,以确定它们的增加与微重力诱导的去条件化之间的关系。这些干浸泡试验在clinicaltrials.gov上注册为女性NCT05043974,男性NCT05493176。
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来源期刊
The FASEB Journal
The FASEB Journal 生物-生化与分子生物学
CiteScore
9.20
自引率
2.10%
发文量
6243
审稿时长
3 months
期刊介绍: The FASEB Journal publishes international, transdisciplinary research covering all fields of biology at every level of organization: atomic, molecular, cell, tissue, organ, organismic and population. While the journal strives to include research that cuts across the biological sciences, it also considers submissions that lie within one field, but may have implications for other fields as well. The journal seeks to publish basic and translational research, but also welcomes reports of pre-clinical and early clinical research. In addition to research, review, and hypothesis submissions, The FASEB Journal also seeks perspectives, commentaries, book reviews, and similar content related to the life sciences in its Up Front section.
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