Unveiling the role of RAI14 in cancer: Biological significance and translational perspectives

IF 2.5 3区医学 Q2 ONCOLOGY

Seminars in oncology Pub Date : 2025-09-02 DOI:10.1016/j.seminoncol.2025.152412

Zhi-Xiong Chong

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引用次数: 0

Abstract

Retinoic acid-induced protein 14 (RAI14) is an actin-binding protein that regulates actin dynamics, cell adhesion, and migration. RAI14 dysregulation has been reported to facilitate the development of at least 10 tumor types based on the findings from over 20 original research articles. This review article aims to fill in the gap in the literature by providing a comprehensive summary of the putative tumor-regulatory roles of RAI14 in different cancers. Overall, RAI14 can affect protein kinase B (AKT), mammalian target of rapamycin, yes-associated protein/Hippo, apoptosis, and epithelial-to-mesenchymal transition activities to promote tumorigenesis. Several noncoding RNAs like miR-23b-3p and AFAP1-AS1 can directly or indirectly affect RAI14 expression to control its tumor-modulatory function epigenetically. Additionally, RAI14 tissue or serum level are overexpressed in at least seven human tumors, including breast, gastrointestinal, genitourinary, and brain cancers. This gives RAI14 the translational potential as a diagnostic or prognostic biomarker. Targeting RAI14 as a cancer antigen can also potentially help halt tumor progression. Future large-scale trials are needed to confirm the tumor-regulatory role of RAI14 in human cancer and to evaluate the sensitivity, reliability, and accuracy of using this target as a biomarker or therapeutic target.

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揭示RAI14在癌症中的作用：生物学意义和翻译观点

视黄酸诱导蛋白14 （Retinoic acid-induced protein 14, RAI14）是一种肌动蛋白结合蛋白，可调节肌动蛋白动力学、细胞粘附和迁移。根据20多篇原创研究文章的发现，RAI14失调已被报道促进了至少10种肿瘤类型的发展。本文旨在通过全面总结RAI14在不同癌症中可能的肿瘤调节作用来填补这一文献空白。总体而言，RAI14可以影响蛋白激酶B （AKT）、哺乳动物雷帕霉素靶点、酵母相关蛋白/Hippo、细胞凋亡和上皮间质转化活性，从而促进肿瘤发生。miR-23b-3p、AFAP1-AS1等几种非编码rna可直接或间接影响RAI14的表达，从表观遗传上控制其肿瘤调节功能。此外，RAI14在至少7种人类肿瘤中组织或血清水平过表达，包括乳腺癌、胃肠道、泌尿生殖系统和脑癌。这使得RAI14具有作为诊断或预后生物标志物的翻译潜力。靶向RAI14作为癌症抗原也可能有助于阻止肿瘤进展。未来的大规模试验需要证实RAI14在人类癌症中的肿瘤调节作用，并评估使用该靶点作为生物标志物或治疗靶点的敏感性、可靠性和准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in oncology 医学-肿瘤学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

104 days

期刊介绍： Seminars in Oncology brings you current, authoritative, and practical reviews of developments in the etiology, diagnosis and management of cancer. Each issue examines topics of clinical importance, with an emphasis on providing both the basic knowledge needed to better understand a topic as well as evidence-based opinions from leaders in the field. Seminars in Oncology also seeks to be a venue for sharing a diversity of opinions including those that might be considered "outside the box". We welcome a healthy and respectful exchange of opinions and urge you to approach us with your insights as well as suggestions of topics that you deem worthy of coverage. By helping the reader understand the basic biology and the therapy of cancer as they learn the nuances from experts, all in a journal that encourages the exchange of ideas we aim to help move the treatment of cancer forward.