Diagnostic laparoscopy and cytoreduction surgery in ovarian cancer FIGO III–IV: The impact on survival of one-stage versus two-stage sequence

IF 4.1 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Gynecologic oncology Pub Date : 2025-09-01 DOI:10.1016/j.ygyno.2025.08.003

Clémence Rebouillat , Christophe Pomel , Nicolas Bourdel , Camille Mimoun , Yohann Dabi , Pierre-Adrien Bolze , Yohan Kerbage , Emilie Raimond , Lise Lecointre , Xavier Carcopino , Canlorbe Geoffroy , Jennifer Uzan , Vincent Lavoué , Cyrille Huchon , Hélène Costaz , Martin Koskas , Cyril Touboul , Lobna Ouldamer , Henri Azaïs , Michel Canis , Pauline Chauvet

{"title":"Diagnostic laparoscopy and cytoreduction surgery in ovarian cancer FIGO III–IV: The impact on survival of one-stage versus two-stage sequence","authors":"Clémence Rebouillat , Christophe Pomel , Nicolas Bourdel , Camille Mimoun , Yohann Dabi , Pierre-Adrien Bolze , Yohan Kerbage , Emilie Raimond , Lise Lecointre , Xavier Carcopino , Canlorbe Geoffroy , Jennifer Uzan , Vincent Lavoué , Cyrille Huchon , Hélène Costaz , Martin Koskas , Cyril Touboul , Lobna Ouldamer , Henri Azaïs , Michel Canis , Pauline Chauvet","doi":"10.1016/j.ygyno.2025.08.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>This is a retrospective study designed to assess the impact of two-stage versus single-stage surgical management on survival in patients with FIGO III-IV ovarian neoplasia receiving surgical management.</div></div><div><h3>Methods</h3><div>This is a retrospective, multicenter study, based on the FRANCOGYN group database. Two groups were studied, the first having primary surgical management in a single operation, and the second having two-stage sequence primary surgical management.</div></div><div><h3>Results</h3><div>208 patients were included in the study. In terms of overall survival, in univariate analysis, there was a statistically significant difference in favor of single-stage surgical management, but this was not demonstrated in multivariate analysis (<em>p</em> = 0,228). Similarly, in terms of recurrence-free survival, there was no statistically significant difference between the two groups studied (p = 0,123).</div></div><div><h3>Conclusion</h3><div>Performing exploratory laparoscopy at the same time as cytoreduction surgery does not significantly improve recurrence-free survival in patients with FIGO III-IV ovarian cancer. This trend was also observed in the overall survival analysis.</div></div>","PeriodicalId":12853,"journal":{"name":"Gynecologic oncology","volume":"201 ","pages":"Pages 167-175"},"PeriodicalIF":4.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gynecologic oncology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0090825825009515","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

This is a retrospective study designed to assess the impact of two-stage versus single-stage surgical management on survival in patients with FIGO III-IV ovarian neoplasia receiving surgical management.

Methods

This is a retrospective, multicenter study, based on the FRANCOGYN group database. Two groups were studied, the first having primary surgical management in a single operation, and the second having two-stage sequence primary surgical management.

Results

208 patients were included in the study. In terms of overall survival, in univariate analysis, there was a statistically significant difference in favor of single-stage surgical management, but this was not demonstrated in multivariate analysis (p = 0,228). Similarly, in terms of recurrence-free survival, there was no statistically significant difference between the two groups studied (p = 0,123).

Conclusion

Performing exploratory laparoscopy at the same time as cytoreduction surgery does not significantly improve recurrence-free survival in patients with FIGO III-IV ovarian cancer. This trend was also observed in the overall survival analysis.

Abstract Image

查看原文本刊更多论文

诊断性腹腔镜和卵巢癌细胞减少手术FIGO III-IV：一期与两期序列对生存的影响

这是一项回顾性研究，旨在评估两期和单期手术治疗对接受手术治疗的FIGO III-IV型卵巢肿瘤患者生存的影响。方法：这是一项基于FRANCOGYN组数据库的回顾性多中心研究。研究了两组，第一组采用单次手术治疗，第二组采用两期顺序手术治疗。结果共纳入208例患者。就总生存率而言，在单因素分析中，支持单阶段手术治疗有统计学显著差异，但在多因素分析中未得到证实（p = 0,228）。同样，在无复发生存率方面，两组间无统计学差异（p = 0,123）。结论腹腔镜探查术同时行细胞减少术并不能显著提高FIGO III-IV型卵巢癌患者的无复发生存率。在总体生存分析中也观察到这一趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Gynecologic oncology 医学-妇产科学

CiteScore

8.60

自引率

6.40%

发文量

1062

审稿时长

37 days

期刊介绍： Gynecologic Oncology, an international journal, is devoted to the publication of clinical and investigative articles that concern tumors of the female reproductive tract. Investigations relating to the etiology, diagnosis, and treatment of female cancers, as well as research from any of the disciplines related to this field of interest, are published. Research Areas Include: • Cell and molecular biology • Chemotherapy • Cytology • Endocrinology • Epidemiology • Genetics • Gynecologic surgery • Immunology • Pathology • Radiotherapy