Disarming a molecular brake: cAMP-responsive element modulator deletion supercharges CAR-NK cells

IF 52.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2025-08-28 DOI:10.1038/s41392-025-02362-0

Sudheendra Hebbar Subramanyam, Klaus Tenbrock

引用次数: 0

Abstract

In a recent study published in Nature, Rafei and colleagues identified the transcription factor cAMP responsive element modulator (CREM) as an important regulator in natural killer (NK) cells that have been engineered with Chimeric antigen receptors (CARs). Their study demonstrated that CREM integrates signals from CAR activation and from interleukin-15 (IL-15) stimulation and serves as a molecular brake that limits CAR-NK functionality.¹

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解除分子制动器：camp响应元件调制器缺失增强CAR-NK细胞

在最近发表在《自然》杂志上的一项研究中，Rafei及其同事发现转录因子cAMP反应元件调节剂（CREM）在嵌合抗原受体（CARs）修饰的自然杀伤（NK）细胞中是一个重要的调节剂。他们的研究表明，CREM整合了来自CAR激活和白细胞介素-15 （IL-15）刺激的信号，并作为限制CAR- nk功能的分子制动器

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.