An important step to translate single-cell measurement into clinical practice: Stereoscopic cells

Abstract

Clinical single-cell biomedicine is an emerging disciplines within molecular medicine that brings more advanced alternatives for disease diagnoses and therapies. With the rapid development of biotechnologies such as Stereo-seq and Stereo-cell, it is now possible to explore the spatiotemporal and dynamical changes of intracellular element and organelle locations, distributions, and functional and morphological phenomes in stereological single cells at multiple layers and orientations. Stereological single cells (StereoCell) will provide the precise multidimensional information on molecular interactions, organelle communications, and signaling pathways, as well as on the interventions involving small molecule-, protein-, and cell-based therapies with targets. This is achieved by integrating morphological images, molecular multi-omics, and clinical phenomics. StereoCell is one of biotechnological breakthroughs and milestones during of clinical translation of single-cell measurements to pathology, biochemistry, hematology, and bioliquid tests. It is also a new approach to discover and develop new diagnostic biomarkers and therapeutic targets, and a new way to dynamically monitor the disease progression and therapeutic effects. Thus, we believe that SereoCell, detected by Stereo-seq and Stereo-cell, will provide new insights into human diseases and reforming clinical practices.