The evolution of antifreeze proteins and the inspiration for the development of novel antifreeze materials

IF 3.2 3区 工程技术 Q2 CHEMISTRY, PHYSICAL
Yihang Gao, Caixia Han and Jianjun Wang
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Abstract

Uncontrolled ice formation poses a significant problem in various industries from atmospheric physics to cryobiology. Therefore, ice controlling strategies including regulating ice nucleation and controlling ice recrystallization and growth are highly pursued. In nature, antifreeze proteins (AFPs) exist in many cold-acclimated species, which can effectively control the size and shape of ice crystals, thus minimizing the deleterious effects of ice. Understanding how nature has evolved AFPs to adapt organisms to cold environments is crucial for guiding the design of novel antifreeze materials by human beings. Herein, we critically reviewed the evolutionary models underlying the development of AFPs, including escape from adaptive conflict (EAC) (primarily involving type III AFPs and Antarctic antifreeze glycoproteins, AFGPs), de novo evolution (exemplified by Arctic codfish AFGPs), horizontal gene transfer (HGT) (represented by type II AFPs and the DUF3494 family), and convergent evolution (predominantly involving type I AFPs and AFGPs). Furthermore, strategies for designing and fabricating bio-inspired antifreeze materials that mirror these evolutionary processes are also discussed. We anticipate that the insights presented here will inspire and aid in the identification of material design strategies for the future development of novel antifreeze materials.

Abstract Image

抗冻蛋白的演变及其对新型抗冻材料开发的启示
不受控制的冰形成在从大气物理学到低温生物学的各个行业中都是一个重大问题。因此,调控冰核和控制冰的再结晶和生长等控冰策略受到高度关注。在自然界中,抗冻蛋白(AFPs)存在于许多冷适应物种中,它可以有效地控制冰晶的大小和形状,从而最大限度地减少冰的有害影响。了解自然界是如何进化出afp以使生物体适应寒冷环境的,对于指导人类设计新型防冻材料至关重要。在此,我们回顾了AFPs发展的进化模型,包括逃避适应性冲突(EAC)(主要涉及III型AFPs和南极抗冻糖蛋白,AFGPs),从头进化(以北极鳕鱼AFGPs为例),水平基因转移(HGT)(以II型AFPs和DUF3494家族为代表),以及趋同进化(主要涉及I型AFPs和AFGPs)。此外,还讨论了设计和制造反映这些进化过程的仿生防冻材料的策略。我们预计,这里提出的见解将启发和帮助在材料设计策略的识别,为未来的新型防冻材料的发展。
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来源期刊
Molecular Systems Design & Engineering
Molecular Systems Design & Engineering Engineering-Biomedical Engineering
CiteScore
6.40
自引率
2.80%
发文量
144
期刊介绍: Molecular Systems Design & Engineering provides a hub for cutting-edge research into how understanding of molecular properties, behaviour and interactions can be used to design and assemble better materials, systems, and processes to achieve specific functions. These may have applications of technological significance and help address global challenges.
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