Copper nanoparticles anchored on guar gum modified magnetic nanoparticles: Investigation of their catalytic efficiency in C-S coupling reactions and their anti-hepatitis cancer properties

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry Pub Date : 2025-08-23 DOI:10.1016/j.jorganchem.2025.123807

Fahad M. Aldosari , Attalla F. El-kott , Mohammed A. AlShehri , Narinderjit Singh Sawaran Singh , Sally Negm , Hiba A. Alarousi , Heba I. Ghamry , Kareem Morsy , Bikash Karmakar

{"title":"Copper nanoparticles anchored on guar gum modified magnetic nanoparticles: Investigation of their catalytic efficiency in C-S coupling reactions and their anti-hepatitis cancer properties","authors":"Fahad M. Aldosari , Attalla F. El-kott , Mohammed A. AlShehri , Narinderjit Singh Sawaran Singh , Sally Negm , Hiba A. Alarousi , Heba I. Ghamry , Kareem Morsy , Bikash Karmakar","doi":"10.1016/j.jorganchem.2025.123807","DOIUrl":null,"url":null,"abstract":"<div><div>In this study, we have presented and detailed a green approach for in situ deactivation of Cu ions and supported Cu NPson guar gum (GG) modified magneticFe3O4 NPs facilitated by Calendula persica extract (Fe3O4/GG@Cu NPs) and the corresponding catalytic and resultant biological applications and effectiveness. We examined the properties of the synthesized Fe3O4/GG@Cu NPs and analyzed it using TEM, FE-SEM, EDX, elemental mapping, VSM, ICP-OES techniques. Additionally, we demonstrated that the prepared Fe3O4/GG@Cu NPs served as an effective catalyst for the production of diaryl sulfides through C-S coupling reactions. Remarkably, the catalyst exhibited remarkable reusability, retaining its effect across 7 recycling runs without significant decline in activity. Using the MTT colorimetric method, we were in a position to expand further investigation to limit the growth of the human hepatic cancer cell line (HepG2). The associated IC50 was found to be 189 µg/mL.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1040 ","pages":"Article 123807"},"PeriodicalIF":2.1000,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organometallic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022328X25003006","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}

引用次数: 0

Abstract

In this study, we have presented and detailed a green approach for in situ deactivation of Cu ions and supported Cu NPson guar gum (GG) modified magneticFe₃O₄ NPs facilitated by Calendula persica extract (Fe₃O₄/GG@Cu NPs) and the corresponding catalytic and resultant biological applications and effectiveness. We examined the properties of the synthesized Fe₃O₄/GG@Cu NPs and analyzed it using TEM, FE-SEM, EDX, elemental mapping, VSM, ICP-OES techniques. Additionally, we demonstrated that the prepared Fe₃O₄/GG@Cu NPs served as an effective catalyst for the production of diaryl sulfides through C-S coupling reactions. Remarkably, the catalyst exhibited remarkable reusability, retaining its effect across 7 recycling runs without significant decline in activity. Using the MTT colorimetric method, we were in a position to expand further investigation to limit the growth of the human hepatic cancer cell line (HepG2). The associated IC₅₀ was found to be 189 µg/mL.

查看原文本刊更多论文

瓜尔胶修饰磁性纳米粒子锚定铜纳米粒子：C-S偶联反应的催化效率及其抗肝癌性质的研究

在这项研究中，我们提出并详细介绍了一种绿色的方法来原位失活Cu离子和负载Cu NPs——瓜尔胶（GG）修饰的磁性Fe3O4 NPs，由金盏花提取物（Fe3O4/GG@Cu NPs）促进，以及相应的催化和由此产生的生物应用和有效性。采用TEM、FE-SEM、EDX、元素映射、VSM、ICP-OES等技术对合成的Fe3O4/GG@Cu纳米粒子的性质进行了表征。此外，我们还证明了制备的Fe3O4/GG@Cu NPs是通过C-S偶联反应生成二硝基硫化物的有效催化剂。值得注意的是，催化剂表现出显著的可重复使用性，在7次循环运行中保持其效果，而活性没有明显下降。使用MTT比色法，我们可以进一步扩展研究以限制人肝癌细胞系（HepG2）的生长。相关IC50值为189µg/mL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.