Aprepitant attenuates cutaneous mast cell migration in oxaliplatin-treated mice

IF 2.9 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of pharmacological sciences Pub Date : 2025-08-25 DOI:10.1016/j.jphs.2025.08.008

Tsugunobu Andoh

引用次数: 0

Abstract

This study investigated whether tachykinin NK1 receptor antagonist aprepitant (APT) inhibits oxaliplatin (OXP)-induced cutaneous mast cell migration in mice. OXP-induced mast cell migration was inhibited by repeated oral administration of APT. OXP increased the expression of monocyte chemotactic protein-1 (MCP-1), stem cell factor (SCF), and interleukin-3 (IL-3), but not platelet-derived endothelial cell growth factor in the plantar skin. APT inhibited OXP-induced MCP-1, but not IL-3, expression. The expression of SCF tended to be inhibited by APT. These results suggest that APT attenuates OXP-induced cutaneous mast cell migration mainly by inhibiting the expression of MCP-1 and SCF.

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阿瑞吡坦减轻奥沙利铂治疗小鼠皮肤肥大细胞的迁移

本研究探讨速激肽NK1受体拮抗剂阿瑞匹坦（aprepitant， APT）是否抑制奥沙利铂（OXP）诱导的小鼠皮肤肥大细胞迁移。反复口服APT可抑制OXP诱导的肥大细胞迁移。OXP可增加足底皮肤单核细胞趋化蛋白-1 （MCP-1）、干细胞因子（SCF）和白细胞介素-3 （IL-3）的表达，但不影响血小板来源的内皮细胞生长因子的表达。APT抑制oxp诱导的MCP-1的表达，但不抑制IL-3的表达。这些结果表明，APT主要通过抑制MCP-1和SCF的表达来减弱oxp诱导的皮肤肥大细胞迁移。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.