Histone acetylation: A key regulator of inflammatory responses

IF 5.1 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-08-26 DOI:10.1016/j.lfs.2025.123936

Siqi Gao , Hua Xiao , Haodang Luo , Xiaoqian Tang , Yanhua Zeng

引用次数: 0

Abstract

Histone acetylation is a critical epigenetic modification that influences several biological processes by altering chromatin structure and regulating gene expression, including chromatin remodeling, DNA replication, transcriptional regulation, signal transduction, autophagy, differentiation, and inflammatory responses. In eukaryotic cells, it ranks as one of the most common posttranslational modifications of histones and the earliest confirmed important positive transcriptional regulators. This review discusses the regulation of histone acetylation on the inflammatory response and comprehensively introduces the influence of histone acetylation on inflammation-related signaling pathways, pathogen infection, and inflammatory diseases. It is expected that this will provide new ideas and insights for the further development and application of histone acetylation inhibitors as therapeutic targets for inflammatory diseases.

Abstract Image

查看原文本刊更多论文

组蛋白乙酰化：炎症反应的关键调节因子

组蛋白乙酰化是一种重要的表观遗传修饰，通过改变染色质结构和调节基因表达来影响多种生物过程，包括染色质重塑、DNA复制、转录调节、信号转导、自噬、分化和炎症反应。在真核细胞中，它是组蛋白最常见的翻译后修饰之一，也是最早被证实的重要的正转录调节因子。本文就组蛋白乙酰化对炎症反应的调控进行综述，全面介绍组蛋白乙酰化对炎症相关信号通路、病原体感染和炎症性疾病的影响。预计这将为进一步开发和应用组蛋白乙酰化抑制剂作为炎症性疾病的治疗靶点提供新的思路和见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.