Monte Carlo study of the eye lens exposure of medical staff administering Sc-47 and Cu-67 labelled radiopharmaceuticals

IF 2.7 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
P. Ferrari , F. Becker , J. Dabin , J. Eakins , Z. Jovanović , D. Krstić , E. Michaś-Majewska , K. Tymińska , A. Benali , R. Bouwman , A. McCann , K. Hürkamp , F. Fioroni
{"title":"Monte Carlo study of the eye lens exposure of medical staff administering Sc-47 and Cu-67 labelled radiopharmaceuticals","authors":"P. Ferrari ,&nbsp;F. Becker ,&nbsp;J. Dabin ,&nbsp;J. Eakins ,&nbsp;Z. Jovanović ,&nbsp;D. Krstić ,&nbsp;E. Michaś-Majewska ,&nbsp;K. Tymińska ,&nbsp;A. Benali ,&nbsp;R. Bouwman ,&nbsp;A. McCann ,&nbsp;K. Hürkamp ,&nbsp;F. Fioroni","doi":"10.1016/j.ejmp.2025.105077","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>In the last decades, new technologies and new radiopharmaceuticals for diagnosis and therapy have continuously grown, and that growth was accompanied by an increasing use in clinical practice, but, as with any other application involving radiation, the extent to which they may contribute to increasing the radiation dose to the operator must be studied. For that reason, EURADOS (European Radiation Dosimetry Group) decided to evaluate the exposure of medical staff in nuclear medicine to new possible radiopharmaceuticals labelled with Sc-47 and Cu-67.</div></div><div><h3>Methodology</h3><div>Modified ICRP voxel model were employed to determine the exposure of the eye lens and of the thyroid of operators administrating radiopharmaceuticals in a typical Peptide Receptor Radionuclide Therapy scenario. The simulations were validated comparing Monte Carlo results with TLD measurements performed in hospital with Lu-177 labelled compounds.</div></div><div><h3>Results</h3><div>Doses to the eye lens and thyroid are derived from the photon emissions (the beta contribution is three order of magnitude lower). The agreement obtained for Lu-177 provides confidence that, notwithstanding the limits of the simulations, the robustness of the followed approach can be extended also to the evaluation performed for Sc-47 and Cu-67.</div></div><div><h3>Conclusions</h3><div>The dose to the lens of the eye is of the order of 2 µSv/GBq per patient for Lu-177 compounds and, due to the different energies and yields, about 8 µSv/GBq for both Sc-47 and Cu-67. These evaluations can be useful to optimize the radiation protection of medical staff in the nuclear medicine environment and assess the correct personnel workload in these kinds of practices.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105077"},"PeriodicalIF":2.7000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physica Medica-European Journal of Medical Physics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1120179725001875","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose

In the last decades, new technologies and new radiopharmaceuticals for diagnosis and therapy have continuously grown, and that growth was accompanied by an increasing use in clinical practice, but, as with any other application involving radiation, the extent to which they may contribute to increasing the radiation dose to the operator must be studied. For that reason, EURADOS (European Radiation Dosimetry Group) decided to evaluate the exposure of medical staff in nuclear medicine to new possible radiopharmaceuticals labelled with Sc-47 and Cu-67.

Methodology

Modified ICRP voxel model were employed to determine the exposure of the eye lens and of the thyroid of operators administrating radiopharmaceuticals in a typical Peptide Receptor Radionuclide Therapy scenario. The simulations were validated comparing Monte Carlo results with TLD measurements performed in hospital with Lu-177 labelled compounds.

Results

Doses to the eye lens and thyroid are derived from the photon emissions (the beta contribution is three order of magnitude lower). The agreement obtained for Lu-177 provides confidence that, notwithstanding the limits of the simulations, the robustness of the followed approach can be extended also to the evaluation performed for Sc-47 and Cu-67.

Conclusions

The dose to the lens of the eye is of the order of 2 µSv/GBq per patient for Lu-177 compounds and, due to the different energies and yields, about 8 µSv/GBq for both Sc-47 and Cu-67. These evaluations can be useful to optimize the radiation protection of medical staff in the nuclear medicine environment and assess the correct personnel workload in these kinds of practices.
使用Sc-47和Cu-67标记的放射性药物的医务人员的眼晶状体暴露的蒙特卡罗研究
目的在过去的几十年里,用于诊断和治疗的新技术和新放射性药物不断发展,这种发展伴随着临床实践中越来越多的使用,但是,与任何其他涉及辐射的应用一样,它们对操作者的辐射剂量增加的程度必须进行研究。因此,EURADOS(欧洲辐射剂量测定组)决定评估核医学医务人员接触标有Sc-47和Cu-67的可能的新放射性药物的情况。方法:采用改进的ICRP体素模型,确定在典型的肽受体放射性核素治疗场景中使用放射性药物的操作人员的晶状体和甲状腺的暴露情况。将蒙特卡罗结果与在医院用Lu-177标记的化合物进行的TLD测量相比较,验证了模拟的有效性。结果对晶状体和甲状腺的剂量来自光子发射(β贡献低三个数量级)。对Lu-177的一致性提供了信心,尽管模拟存在局限性,但后续方法的鲁棒性也可以扩展到对Sc-47和Cu-67进行的评估。结论Lu-177化合物对患者晶状体的剂量约为2 μ Sv/GBq, Sc-47和Cu-67由于能量和产率不同,对患者晶状体的剂量约为8 μ Sv/GBq。这些评价有助于优化核医学环境中医务人员的辐射防护,并评估此类实践中正确的人员工作量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.80
自引率
14.70%
发文量
493
审稿时长
78 days
期刊介绍: Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics: Medical Imaging Radiation Therapy Radiation Protection Measuring Systems and Signal Processing Education and training in Medical Physics Professional issues in Medical Physics.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信