Clinical applications of circulating tumor cells in metastasis and therapy

IF 40.4 1区 医学 Q1 HEMATOLOGY
Chuan Yang, Can Liu, Chenglai Xia, Liwu Fu
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引用次数: 0

Abstract

Circulating tumor cells (CTCs), which serve as an early indicator of tumors in peripheral blood, are closely associated with unfavorable prognoses in individuals with cancer. Gaining a thorough understanding of the heterogeneity and specific trajectory of CTCs during metastasis can yield valuable insights for the development of effective cancer treatment strategies. This review critically examines the contemporary knowledge of the in vivo process of CTCs, with a focus on the four key stages: dissemination, homing, colonization, and macro-metastasis. Each stage is discussed in terms of its associated characteristics, including epithelial-mesenchymal transition (EMT), dormancy, organotropism, and awakening. We also discuss recent advancements in CTC isolation, detection, cultivation and its potential applications. Additionally, it provides a comprehensive elucidation of the intricate mechanisms of immune evasion and drug resistance in CTCs, aiming to identify novel targets for cancer therapy. Finally, an overview of CTC interventions is presented, which may facilitate the development of personalized therapeutic approaches for patients and improve their metastasis-free prognostic outcomes.
循环肿瘤细胞在转移及治疗中的临床应用
循环肿瘤细胞(CTCs)作为外周血肿瘤的早期指标,与癌症患者的不良预后密切相关。深入了解ctc在转移过程中的异质性和特定轨迹可以为开发有效的癌症治疗策略提供有价值的见解。这篇综述批判性地考察了ctc在体内过程的当代知识,重点关注四个关键阶段:传播、归巢、定植和大转移。每个阶段都根据其相关特征进行讨论,包括上皮-间质转化(EMT)、休眠、器官亲和性和觉醒。本文还讨论了CTC的分离、检测、培养及其潜在应用的最新进展。此外,它还全面阐明了ctc免疫逃避和耐药的复杂机制,旨在发现癌症治疗的新靶点。最后,概述了CTC干预措施,这可能有助于患者个性化治疗方法的发展,并改善其无转移预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
48.10
自引率
2.10%
发文量
169
审稿时长
6-12 weeks
期刊介绍: The Journal of Hematology & Oncology, an open-access journal, publishes high-quality research covering all aspects of hematology and oncology, including reviews and research highlights on "hot topics" by leading experts. Given the close relationship and rapid evolution of hematology and oncology, the journal aims to meet the demand for a dedicated platform for publishing discoveries from both fields. It serves as an international platform for sharing laboratory and clinical findings among laboratory scientists, physician scientists, hematologists, and oncologists in an open-access format. With a rapid turnaround time from submission to publication, the journal facilitates real-time sharing of knowledge and new successes.
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