Enlarged choroid plexus is associated with reduced gray matter volumes and increased plasma amyloid-beta: a population-based study of older adults

IF 3.3 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-08-22 DOI:10.1016/j.ejrad.2025.112372

Qianqian Xie , Ziwei Chen , Jiafeng Wang , Yan Wang , Huisi Zhang , Xiaoyu Wang , Chunyan Li , Yongxiang Wang , Lin Cong , Lin Song , Yifeng Du , Chengxuan Qiu

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引用次数: 0

Abstract

Objectives

To characterize brain structures and plasma Alzheimer’s-related biomarkers associated with enlarged choroid plexus (ChP) among rural older adults in China.

Methods

This population-based cross-sectional study included 1115 older adults (age ≥ 60 years) derived from the Multimodal Interventions to delay Dementia and disability in rural China, who underwent structural brain MRI scans (3.0 T) in 2018–2020; of these, plasma biomarkers for Alzheimer’s disease and neurodegeneration, i.e., β-amyloid (Aβ) 40, Aβ42, neurofilament light chain (NfL), and total tau, were measured using the Simoa platform for 814 persons. ChP was automatically segmented and quantified on T1-weighted images. Data were analyzed using the voxel-based morphometry (VBM) analysis, general linear regression model, and mediation model.

Results

The enlarged ChP volume was significantly associated with reduced gray matter volume (GMV) mainly in the insular region, hippocampus, parahippocampal gyrus, and left thalamus (P < 0.05). In the plasma biomarker subsample, larger ChP volume was associated with higher plasma Aβ40 and Aβ42, and the association was significant only in men (P for ChP volume × sex interaction < 0.05). The mediation analysis suggested that plasma Aβ40 significantly mediated the association of enlarged ChP volume with the reduced GMV of insular region, hippocampus, and left thalamus in men, with the proportion of mediation being 10.73 %, 6.32 %, and 11.45 %, respectively.

Conclusions

Enlarged ChP volume was associated with reduced regional GMV and increased plasma Aβ40 in older adults, suggesting that the enlarged ChP might be a neuroimaging marker for the brain aging.

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脉络膜丛增大与灰质体积减少和血浆β淀粉样蛋白增加有关：一项基于老年人的人群研究

目的研究中国农村老年人与脉络膜丛扩大（ChP）相关的脑结构和血浆阿尔茨海默病相关生物标志物。方法：这项基于人群的横断面研究纳入了1115名老年人（年龄≥60岁），这些老年人来自中国农村的多模式干预措施，以延缓痴呆症和残疾，他们在2018-2020年接受了脑结构MRI扫描（3.0 T）；其中，阿尔茨海默病和神经变性的血浆生物标志物，即β-淀粉样蛋白（Aβ） 40, Aβ42，神经丝轻链（NfL）和总tau，使用Simoa平台对814人进行了测量。在t1加权图像上对ChP进行自动分割和量化。数据分析采用基于体素的形态计量学（VBM）分析、一般线性回归模型和中介模型。结果ChP体积增大与脑岛区、海马区、海马旁回和左丘脑灰质体积减少显著相关（P < 0.05）。在血浆生物标志物亚样本中，较大的ChP体积与较高的血浆Aβ40和Aβ42相关，且仅在男性中存在显著相关性（ChP体积×性别相互作用P = 0.05）。血浆Aβ40介导ChP体积增大与男性岛区、海马体、左丘脑GMV降低之间的关联，其介导比例分别为10.73%、6.32%、11.45%。结论ChP体积增大与老年人局部GMV降低、血浆a β40升高相关，提示ChP体积增大可能是脑老化的神经影像学标志。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.