{"title":"Lightweight self-attention and deep gated neural network (LSA-DGNet) for multiple neurological disease detection","authors":"Shraddha Jain , Rajeev Srivastava , Sukomal Pal","doi":"10.1016/j.compbiolchem.2025.108621","DOIUrl":null,"url":null,"abstract":"<div><div>Detecting neurological diseases is an important task in modern medicine, for which it is crucial to accurately model the temporal distributions of disease genesis. In prior methodologies, temporal patterns are used in feature effects and limiting assumptions such as proportionate risks. We introduce a new methodology for neural disease diagnosis, known as LSA-DGNet (Lightweight Self-Attention based on Deep Gated Network). LSA-DGNet utilizes a deep gated neural network module to model nonlinear and time-lagged effects of variables on disease outcomes. We combined multi-scale time-aware self-attention modules with scaled dot-product self-attention modules so that the parallel structures could provide an integrated self-attention mechanism to improve data perception. LSA-DGNet addresses both issues and, hence, sets a new benchmark for real-time, accurate detection of neurological diseases. Unlike existing approaches, LSA-DGNet integrates a lightweight multi-scale time-aware self-attention mechanism with deep gated neural networks, enabling improved modeling of temporal dependencies in noisy EEG data. This design allows for accurate and efficient detection of multiple neurological diseases, validated on five real-world datasets, setting new benchmarks in classification performance. With up to 250 frames a second, it indicant large progress in computational efficiency—game-changer potential—and clinical applications. The entire framework opens up new opportunities for early diagnosis and more tailored treatment strategies and simply revolutionizes how neurological diseases are detected and treated.</div></div>","PeriodicalId":10616,"journal":{"name":"Computational Biology and Chemistry","volume":"120 ","pages":"Article 108621"},"PeriodicalIF":3.1000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computational Biology and Chemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1476927125002828","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Detecting neurological diseases is an important task in modern medicine, for which it is crucial to accurately model the temporal distributions of disease genesis. In prior methodologies, temporal patterns are used in feature effects and limiting assumptions such as proportionate risks. We introduce a new methodology for neural disease diagnosis, known as LSA-DGNet (Lightweight Self-Attention based on Deep Gated Network). LSA-DGNet utilizes a deep gated neural network module to model nonlinear and time-lagged effects of variables on disease outcomes. We combined multi-scale time-aware self-attention modules with scaled dot-product self-attention modules so that the parallel structures could provide an integrated self-attention mechanism to improve data perception. LSA-DGNet addresses both issues and, hence, sets a new benchmark for real-time, accurate detection of neurological diseases. Unlike existing approaches, LSA-DGNet integrates a lightweight multi-scale time-aware self-attention mechanism with deep gated neural networks, enabling improved modeling of temporal dependencies in noisy EEG data. This design allows for accurate and efficient detection of multiple neurological diseases, validated on five real-world datasets, setting new benchmarks in classification performance. With up to 250 frames a second, it indicant large progress in computational efficiency—game-changer potential—and clinical applications. The entire framework opens up new opportunities for early diagnosis and more tailored treatment strategies and simply revolutionizes how neurological diseases are detected and treated.
期刊介绍:
Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered.
Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated. In the absence of experimental results for validation, the use of molecular dynamics simulations along with detailed free energy calculations, for example, should be used as complementary techniques to support the major conclusions. Submissions of premature modeling exercises without additional biological insights will not be considered.
Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis, which will be evaluated by the editors.