Factors delaying the administration of tissue plasminogen activator (tPA) to acute ischemic stroke patients according to nurses’ perspective

Q2 Nursing

International Journal of Africa Nursing Sciences Pub Date : 2025-01-01 DOI:10.1016/j.ijans.2025.100884

Mahboobeh Mohammadnezhad , Sadra Ashrafi , Atefeh Ghanbari Khanghah , Saman Maroufizadeh , Tahereh Khaleghdoost Mohammadi

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引用次数: 0

Abstract

Background

Prompt administration of tissue plasminogen activator(tPA) is a key factor in improving acute stroke outcomes. Several reasons contribute to the delayed application of this therapy in patients with acute ischemic stroke.

Objective

To examine the factors delaying the administration of tissue plasminogen activator (tPA) from nurses’ perspective.

Method

This cross-sectional analytical study was conducted on 97 nurses working in Poursina Hospital (Rasht, Iran) selected via the census method. The data were collected using a researcher-made form developed based on the literature. The form included a demographic questionnaire and a checklist of common delay factors. The data were analyzed in SPSS 16.

Results

There was a statistically significant difference between the scores of delay factors (χ2 = 97.84, P < 0.001). Overall, the most important delay factors were related to patients and their companions, neurologist, laboratory, imaging, hospital equipment and other treatment staff, and nursing staff, in the order of their appearance.

Conclusion

According to the nurses, the most important delay factors were related to patients and their companions. Also, the most important factor in this category was the delay caused by the consent of patients’ families due to their lack of knowledge about the benefits and side effects of the medication. Therefore, it is crucial to raise awareness quickly and obtain the consent of the family for tPA administration at the time of the patient’s arrival.

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从护士角度分析急性缺血性脑卒中患者延迟使用组织型纤溶酶原激活剂的因素

背景：及时给予组织型纤溶酶原激活剂（tPA）是改善急性脑卒中预后的关键因素。有几个原因导致这种治疗延迟应用于急性缺血性脑卒中患者。目的从护士角度探讨延迟组织型纤溶酶原激活剂（tPA）使用的因素。方法采用横断面分析方法，对伊朗Rasht市Poursina医院97名护士进行调查。数据收集使用的是基于文献开发的研究者自制表格。该表格包括一份人口调查问卷和一份常见延迟因素清单。数据采用SPSS 16进行分析。结果两组患者延迟因素得分差异有统计学意义（χ2 = 97.84, P < 0.001）。总体而言，最重要的延迟因素依次为患者及其陪伴者、神经科医生、实验室、影像、医院设备等治疗人员和护理人员。结论护士认为最重要的延迟因素与患者及其陪伴者有关。此外，这一类别中最重要的因素是患者家属由于不了解药物的益处和副作用而同意导致的延误。因此，在患者到达时迅速提高认识并获得家属对tPA施用的同意至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Africa Nursing Sciences Nursing-Nursing (all)

CiteScore

2.40

自引率

0.00%

发文量

114

审稿时长

21 weeks

期刊介绍： International Journal of Africa Nursing Sciences (IJANS) is an international scientific journal published by Elsevier. The broad-based journal was founded on two key tenets, i.e. to publish the most exciting research with respect to the subjects of Nursing and Midwifery in Africa, and secondly, to advance the international understanding and development of nursing and midwifery in Africa, both as a profession and as an academic discipline. The fully refereed journal provides a forum for all aspects of nursing and midwifery sciences, especially new trends and advances. The journal call for original research papers, systematic and scholarly review articles, and critical papers which will stimulate debate on research, policy, theory or philosophy of nursing as related to nursing and midwifery in Africa, technical reports, and short communications, and which will meet the journal''s high academic and ethical standards. Manuscripts of nursing practice, education, management, and research are encouraged. The journal values critical scholarly debate on issues that have strategic significance for educators, practitioners, leaders and policy-makers of nursing and midwifery in Africa. The journal publishes the highest quality scholarly contributions reflecting the diversity of nursing, and is also inviting international scholars who are engaged with nursing and midwifery in Africa to contribute to the journal. We will only publish work that demonstrates the use of rigorous methodology as well as by publishing papers that highlight the theoretical underpinnings of nursing and midwifery as it relates to the Africa context.