Lei Shi, Hong xia Che, Huan Yang, Yang yang Li, Yuan yuan Jin
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引用次数: 0
Abstract
Diabetes, a collection of metabolic syndromes, is a significant global health issue. One of the most prevalent microvascular complications of diabetes that is linked to excessive blood sugar levels is diabetic neuropathy (DN). DN frequently necessitates prolonged therapy and may persist following treatment, which could have a negative impact on the individual's quality of life. The crucial management of DN still requires the development of efficient therapies, regardless of the continuous discovery of new drugs. A novel innovation and advancement in the treatment of diabetes and diabetes-related complications has been the emergence of mesenchymal stem cells (MSCs). Compared to their parent donors, MSC-derived extracellular vesicles (MSC-EVs) have shown considerable potential as a unique cell-free method that reprograms damaged cells by initiating regenerative processes. Increasingly, research has demonstrated that MSC-EVs transfer a variety of biological compounds to establish a beneficial microenvironment, thereby playing an important role in alleviating diabetic complications. The objective of this review was to offer a comprehensive perspective on the utilization of MSC-derived EVs in DN, as well as to discuss recent developments and potential challenges to improve their efficacy in DN.
期刊介绍:
The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents. The scope includes effects on the organism at all stages of development, on organ systems, tissues, and cells as well as on enzymes, receptors, hormones, and genes. The biochemical and molecular aspects of uptake, transport, storage, excretion, lactivation and detoxication of drugs, agricultural, industrial and environmental chemicals, natural products and food additives are all subjects suitable for publication. Of particular interest are aspects of molecular biology related to biochemical toxicology. These include studies of the expression of genes related to detoxication and activation enzymes, toxicants with modes of action involving effects on nucleic acids, gene expression and protein synthesis, and the toxicity of products derived from biotechnology.