Therapeutic Applications of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Diabetic Neuropathy; Challenges and Future Prospective

IF 2.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Lei Shi, Hong xia Che, Huan Yang, Yang yang Li, Yuan yuan Jin
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Abstract

Diabetes, a collection of metabolic syndromes, is a significant global health issue. One of the most prevalent microvascular complications of diabetes that is linked to excessive blood sugar levels is diabetic neuropathy (DN). DN frequently necessitates prolonged therapy and may persist following treatment, which could have a negative impact on the individual's quality of life. The crucial management of DN still requires the development of efficient therapies, regardless of the continuous discovery of new drugs. A novel innovation and advancement in the treatment of diabetes and diabetes-related complications has been the emergence of mesenchymal stem cells (MSCs). Compared to their parent donors, MSC-derived extracellular vesicles (MSC-EVs) have shown considerable potential as a unique cell-free method that reprograms damaged cells by initiating regenerative processes. Increasingly, research has demonstrated that MSC-EVs transfer a variety of biological compounds to establish a beneficial microenvironment, thereby playing an important role in alleviating diabetic complications. The objective of this review was to offer a comprehensive perspective on the utilization of MSC-derived EVs in DN, as well as to discuss recent developments and potential challenges to improve their efficacy in DN.

Abstract Image

间充质干细胞来源的细胞外囊泡在糖尿病神经病变中的应用挑战与未来展望
糖尿病是一系列代谢综合征的集合,是一个重大的全球健康问题。糖尿病神经病变(DN)是糖尿病最常见的微血管并发症之一,与血糖水平过高有关。DN经常需要长期治疗,并可能在治疗后持续存在,这可能对个人的生活质量产生负面影响。不管新药的不断发现,关键的DN管理仍然需要开发有效的治疗方法。间充质干细胞(MSCs)的出现是糖尿病及糖尿病相关并发症治疗的一项创新和进展。与它们的母体供体相比,msc来源的细胞外囊泡(msc - ev)已经显示出相当大的潜力,作为一种独特的无细胞方法,通过启动再生过程对受损细胞进行重编程。越来越多的研究表明,msc - ev可以转移多种生物化合物,建立有益的微环境,从而在减轻糖尿病并发症方面发挥重要作用。本综述的目的是提供一个全面的观点,利用msc衍生的EVs在DN,并讨论最近的发展和潜在的挑战,以提高其在DN的疗效。
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来源期刊
CiteScore
5.80
自引率
2.80%
发文量
277
审稿时长
6-12 weeks
期刊介绍: The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents. The scope includes effects on the organism at all stages of development, on organ systems, tissues, and cells as well as on enzymes, receptors, hormones, and genes. The biochemical and molecular aspects of uptake, transport, storage, excretion, lactivation and detoxication of drugs, agricultural, industrial and environmental chemicals, natural products and food additives are all subjects suitable for publication. Of particular interest are aspects of molecular biology related to biochemical toxicology. These include studies of the expression of genes related to detoxication and activation enzymes, toxicants with modes of action involving effects on nucleic acids, gene expression and protein synthesis, and the toxicity of products derived from biotechnology.
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