Risk for Sleep-Disordered Breathing Among Children and Adolescents With Perinatal Stroke and the Impact on Mental Health, Quality of Life, and Caregivers

IF 2.1 3区医学 Q2 CLINICAL NEUROLOGY

Pediatric neurology Pub Date : 2025-08-06 DOI:10.1016/j.pediatrneurol.2025.07.019

Lisa Smithson PhD , Muhammad Khan MD, CCFP , Jacqueline Pei R.Psych, PhD , John Andersen MD , Jerome Yager MD , Piushkumar Mandhane MD, PhD , Adam Kirton MD, MSc , Carmen Rasmussen PhD

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Abstract

Background

Perinatal stroke is a leading cause of cerebral palsy and lifelong neurological disability and a potential risk factor for sleep-disordered breathing (SDB).

Methods

We examined the risk for SDB and associated psychosocial outcomes among 77 children with perinatal stroke. Caregivers completed validated questionnaires evaluating their children's sleep (Pediatric Sleep Questionnaire), mental health (Behavior Assessment System for Children, Third Edition [BASC-3]), and quality of life (Pediatric Quality of Life Inventory [PedsQL]) as well as the psychosocial impact on themselves (Parental Outcome Measure [POM]).

Results

The risk of SDB (SDB ratio of 0.33 or higher) in children with perinatal stroke was 34%. SDB symptomology was adversely associated with composite measures assessed by the BASC-3 including Externalizing and Internalizing Problems, Behavioral Symptoms Index, and Adaptability. SDB symptoms were associated with greater impairment in the following domains of the PedsQL: Daily Activities, Movement and Balance, Pain and Hurt, Fatigue, and Eating Activities. SDB symptomatology was also correlated with worse psychosocial impact and overall caregiver outcomes on the POM.

Conclusions

In conclusion, SDB symptoms are prevalent in children with perinatal stroke and may be associated with adverse psychosocial outcomes for children and caregivers. As a treatable modifier of long-term outcomes, increased awareness, screening, and study are required.

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围产期中风儿童和青少年睡眠呼吸障碍的风险及其对心理健康、生活质量和护理人员的影响

背景围产期中风是脑瘫和终身神经功能障碍的主要原因，也是睡眠呼吸障碍（SDB）的潜在危险因素。方法对77例围产期脑卒中患儿进行SDB发病风险及相关社会心理结局分析。照顾者完成了有效的问卷，评估孩子的睡眠（儿科睡眠问卷）、心理健康（儿童行为评估系统，第三版[BASC-3]）、生活质量（儿科生活质量量表[PedsQL]）以及对自己的心理社会影响（父母结局量表[POM]）。结果围产期脑卒中患儿发生SDB的风险为34% （SDB比值大于等于0.33）。SDB的症状与BASC-3评估的综合指标（包括外化和内化问题、行为症状指数和适应性）呈负相关。SDB症状与以下PedsQL领域的更大损害相关：日常活动、运动和平衡、疼痛和伤害、疲劳和饮食活动。SDB症状也与POM患者较差的社会心理影响和整体护理结果相关。结论SDB症状在围产期脑卒中患儿中普遍存在，并可能与患儿及其照料者的不良心理社会结局相关。作为一种可治疗的长期预后调节剂，需要提高认识、筛查和研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.