Evaluation of the dosimetric accuracy of HyperSight CBCT for CBCT-only adaptive radiotherapy workflow

IF 2.7 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Physica Medica-European Journal of Medical Physics Pub Date : 2025-08-23 DOI:10.1016/j.ejmp.2025.105091

Francesca Dusi, Fabio Busato, Alessandro Testolin, Davide Fiorentin, Francesca Tessari, Mattia Nicoletto, Marco Fusella

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引用次数: 0

Abstract

Background/introduction

This study evaluates the dosimetric performance of HyperSight CBCT (HS-CBCT) images for CBCT-only adaptive radiotherapy workflows.

Methods

We evaluated Hounsfield unit (HU) accuracy and dose calculation performance using both Feldkamp-Davis-Kress (FDK) and Acuros reconstructions in phantom and clinical datasets (brain, breast, pelvis). HU deviations were reported relative to planning CT. Longitudinal HU stability was assessed over 20 CBCT sessions in a prostate cohort. Gamma passing rates (2 %/2mm) were used for dosimetric evaluation.

Results

Acuros-reconstructed CBCT images demonstrated HU agreement within 28 HU of the planning CT, compared to deviations up to 284 HU for FDK (the relative coefficient of variation −CV- of the difference from the pCT reference value were 2 % and 20 % for Acuros and FDK respectively). Dose recalculations on Acuros images resulted in higher gamma passing rates, particularly in pelvic cases (97.8 % vs 96.6 % with FDK, p < 0.05). HU stability analysis over 20 CBCT sessions in prostate patients confirmed reproducibility, with standard deviations of 5.0 HU for bone and 4.2 HU for bladder.

Conclusion

This study provides the first comprehensive, multi-site and longitudinal clinical validation of HyperSight CBCT with Acuros reconstruction for ART workflows. Our results demonstrate high HU fidelity and robust dose calculation performance, supporting the clinical feasibility of CBCT-only workflows across different anatomical regions and throughout the course of treatment.

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评价HyperSight CBCT在全CBCT自适应放疗工作流程中的剂量学准确性

背景/介绍本研究评估HyperSight CBCT （HS-CBCT）图像在仅CBCT自适应放疗工作流程中的剂量学性能。方法采用Feldkamp-Davis-Kress （FDK）和Acuros重建模型对幻影和临床数据集（脑、乳腺、骨盆）的Hounsfield单位（HU）精度和剂量计算性能进行评估。HU偏差报告相对于计划CT。纵向HU稳定性在前列腺队列中进行了超过20次的CBCT评估。伽玛通过率（2% /2mm）用于剂量学评价。结果acros和FDK与pCT参考值差异的相对变异系数- CV-分别为2%和20%，而acros和FDK与pCT参考值的差异最大可达284 HU。在Acuros图像上重新计算剂量导致更高的伽马通过率，特别是在骨盆病例中（97.8% vs 96.6% FDK, p < 0.05）。对前列腺患者20次CBCT的HU稳定性分析证实了可重复性，骨和膀胱的标准偏差分别为5.0 HU和4.2 HU。结论本研究首次对HyperSight CBCT与acros重建在ART工作流程中的应用进行了全面、多部位、纵向的临床验证。我们的研究结果显示了高HU保真度和强大的剂量计算性能，支持跨不同解剖区域和整个治疗过程中仅cbct工作流程的临床可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physica Medica-European Journal of Medical Physics 生物-生物物理

CiteScore

6.80

自引率

14.70%

发文量

493

审稿时长

78 days

期刊介绍： Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics: Medical Imaging Radiation Therapy Radiation Protection Measuring Systems and Signal Processing Education and training in Medical Physics Professional issues in Medical Physics.