Association between triglyceride glucose-weight-adjusted waist index and stroke risk in the general population: A large cross-sectional study from NHANES

IF 1.8 4区医学 Q3 NEUROSCIENCES

Journal of Stroke & Cerebrovascular Diseases Pub Date : 2025-08-20 DOI:10.1016/j.jstrokecerebrovasdis.2025.108434

Quanhong Chu , Yaoyao Shen , Shimin Liu , Wei Rao , An Wen , Lingfeng Wu , Wenfeng Cao

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引用次数: 0

Abstract

Background

Insulin resistance (IR) is closely associated with stroke risk. The triglyceride glucose-weight-adjusted waist index (TyG-WWI) is a novel biomarker for IR estimation. However, the relationship between the TyG-WWI index and stroke risk in the general population remains unexplored. This study aims to explore the potential relationship between the TyG-WWI index and stroke risk in the general population.

Methods

A total of 22,615 participants from the 1999–2018 NHANES programme were included in this study. Multivariate logistic regression models, restricted cubic spline regression, subgroup analyses and sensitivity analysis were performed to explore the relationship between the TyG-WWI index and stroke risk in the general population.

Results

Among the 22,615 participants included in the study, 812 participants were identified as stroke patients. After adjusting for multiple confounders, multivariate logistic regression analyses indicated that each SD (standard deviation) increase in the TyG-WWI index was associated with a 15 % increase in the risk of stroke (OR: 1.15, 95 % CI: 1.01–1.32). The further restricted cubic spline analysis demonstrated a positive linear relationship between the TyG-WWI index and stroke risk (p for non-linearity: 0.149). Subgroup analysis showed a more pronounced association between the TyG-WWI index and stroke risk among younger participants and those without coronary heart disease. Finally, sensitivity analysis consistently confirmed the robustness of the study findings.

Conclusions

The findings indicate a positive linear relationship between the TyG-WWI index and stroke risk in the general population.

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甘油三酯-葡萄糖-体重调整腰围指数与普通人群中风风险之间的关系：来自NHANES的一项大型横断面研究

背景：胰岛素抵抗（insulin resistance， IR）与卒中风险密切相关。甘油三酯-葡萄糖-体重调节腰围指数（TyG-WWI）是一种新的IR评价生物标志物。然而，TyG-WWI指数与普通人群中风风险之间的关系仍未得到研究。本研究旨在探讨TyG-WWI指数与普通人群卒中风险之间的潜在关系。方法本研究共纳入1999-2018年NHANES项目的22,615名参与者。采用多元logistic回归模型、受限三次样条回归、亚组分析和敏感性分析探讨TyG-WWI指数与普通人群卒中风险的关系。结果在纳入研究的22615名参与者中，812名参与者被确定为中风患者。在对多个混杂因素进行调整后，多变量logistic回归分析表明，TyG-WWI指数每增加一个标准差，卒中风险就增加15% （OR: 1.15, 95% CI: 1.01-1.32）。进一步的限制三次样条分析显示TyG-WWI指数与卒中风险呈正线性关系（非线性p为0.149）。亚组分析显示，在年轻参与者和没有冠心病的参与者中，TyG-WWI指数与中风风险之间的关联更为明显。最后，敏感性分析一致地证实了研究结果的稳健性。结论在普通人群中，TyG-WWI指数与卒中风险呈线性正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stroke & Cerebrovascular Diseases Medicine-Surgery

CiteScore

5.00

自引率

4.00%

发文量

583

审稿时长

62 days

期刊介绍： The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.