SensRORing cholesterol to drive protumoral myelopoiesis.

Abstract

Protumoral myelopoiesis is a determinant of immunoevasion and tumor spread in many malignancies. In a recent issue of Cancer Discovery, Bleve and colleagues point to cholesterol-driven RORγ activation as the molecular trigger of myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) expansion, resulting in defective antitumor response and disease progression.