Sean Lei, Abhirami Shankar, Supreet Sethi, Erik L Lum
{"title":"Kidney transplantation between identical twins with APOL1 homozygote risk alleles - a case report.","authors":"Sean Lei, Abhirami Shankar, Supreet Sethi, Erik L Lum","doi":"10.3389/fneph.2025.1648263","DOIUrl":null,"url":null,"abstract":"<p><p>Kidney transplantation is the optimal therapy for individuals with end-stage kidney disease. Recent studies suggest a negative impact of high-risk Apolipoprotein L1 genotypes on outcomes for both living kidney donors and kidney transplant recipients. In this case, we describe a pair of identical twins with a high-risk APOL1 genotype who underwent successful living kidney transplantation with excellent short-term outcomes.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"5 ","pages":"1648263"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350138/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in nephrology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fneph.2025.1648263","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Kidney transplantation is the optimal therapy for individuals with end-stage kidney disease. Recent studies suggest a negative impact of high-risk Apolipoprotein L1 genotypes on outcomes for both living kidney donors and kidney transplant recipients. In this case, we describe a pair of identical twins with a high-risk APOL1 genotype who underwent successful living kidney transplantation with excellent short-term outcomes.