Pilot Study: Improving Glycemic Control Among Children and Adolescents With Obesity and Prediabetes With Real-Time Feedback Via Continuous Glucose Monitoring.

Q3 Medicine

Diabetes Spectrum Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI:10.2337/ds24-0051

Zachary Z Mayer, Timothy P Foster, Xiaofei Chi, Michael A Tan, Matthew J Gurka, Angelina V Bernier

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Abstract

Objective: To assess the feasibility and efficacy of a novel use of continuous glucose monitoring (CGM) in prediabetes to promote behavioral change and improve glycemia.

Research design and methods: We conducted a single-arm prospective study in a pediatric obesity clinic to evaluate the feasibility and acceptability of wearing a CGM sensor in children aged 10-17 years with obesity (BMI ≥95th percentile for age) and prediabetes. Feasibility was determined through participant recruitment. We analyzed differences in A1C, glucose variability, BMI, and dietary intake at 12 weeks.

Results: Of 22 participants recruited, 14 completed the study. Over 12 weeks, the mean BMI percentage of the 95th percentile decreased from 153.4 to 150.1% (P = 0.006), daily estimated carbohydrate consumption decreased by 41.4% (P = 0.009), and A1C decreased by 0.2% (P = 0.03).

Conclusion: CGM in an adolescent population with prediabetes and obesity may be a helpful adjunct to therapy to improve A1C, support dietary changes, reduce the rate of weight gain, and attenuate diabetes risk.

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试点研究：通过持续血糖监测实时反馈改善肥胖和前驱糖尿病儿童和青少年的血糖控制。

目的：探讨持续血糖监测（CGM）在糖尿病前期促进行为改变和改善血糖的可行性和有效性。研究设计和方法：我们在一家儿童肥胖诊所进行了一项单臂前瞻性研究，以评估10-17岁肥胖（BMI≥95百分位）和前驱糖尿病儿童佩戴CGM传感器的可行性和可接受性。通过参与者招募确定可行性。我们分析了12周时A1C、葡萄糖变异性、BMI和饮食摄入量的差异。结果：在招募的22名参与者中，有14人完成了研究。在12周内，第95百分位的平均BMI百分比从153.4下降到150.1% (P = 0.006)，每日估计碳水化合物消耗量下降41.4% (P = 0.009)， A1C下降0.2% （P = 0.03）。结论：青少年糖尿病前期和肥胖人群的CGM可能是改善A1C、支持饮食改变、降低体重增加率和降低糖尿病风险的有益辅助治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes Spectrum Medicine-Internal Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： The mission of Diabetes Spectrum: From Research to Practice is to assist health care professionals in the development of strategies to individualize treatment and diabetes self-management education for improved quality of life and diabetes control. These goals are achieved by presenting review as well as original, peer-reviewed articles on topics in clinical diabetes management, professional and patient education, nutrition, behavioral science and counseling, educational program development, and advocacy. In each issue, the FROM RESEARCH TO PRACTICE section explores, in depth, a diabetes care topic and provides practical application of current research findings.