Factors Influencing Prolonged Hospital Stay in Surgically Treated Children and Adolescents with Left-to-Right Shunt Congenital Heart Disease: Evidence From a Hospital in Southern China.

IF 2.8 3区 医学 Q1 Pharmacology, Toxicology and Pharmaceutics
Therapeutics and Clinical Risk Management Pub Date : 2025-08-10 eCollection Date: 2025-01-01 DOI:10.2147/TCRM.S533273
Liudan Huang, Yuhua Zhang, Shaobo Jiang
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Abstract

Background: Congenital heart disease(CHD) is a congenital malformation caused by abnormal development of the heart and large blood vessels, and left-to-right shunt CHD is a relatively common type. Surgical treatment has the problem of prolonged hospital stay in CHD patients. It is of great significance to explore the influencing factors of prolonged hospital stay after surgery therapy for children and adolescents with left-to-right shunt CHD.

Methods: A total of 463 children and adolescents with left-to-right shunt CHD who received surgery therapy were retrospectively analyzed. Medical records (gender, CHD types, echocardiography, invasive mechanical ventilation, blood transfusion, tracheal intubation, intraoperative blood loss, and length of hospital stay) were collected. The threshold for prolonged hospital stay was defined based on the third quartile (75th percentile) of length of hospital stay in all patients. The relationship between clinical features and prolonged hospital stay was analyzed.

Results: The mean length of hospital stay was 13.00 (7.00, 18.00) days, there were 330 (71.3%) patients with non-prolonged hospital stay (<18.0 days) and 133 (28.7%) with prolonged stay (≥18.0 days). There were statistically significant differences in the distributions of types of CHD (χ2=67.959, p<0.001), severity of mitral insufficiency (χ2=14.171, p=0.002) and pulmonary hypertension (χ2=49.611, p<0.001), and the proportion of treated with invasive mechanical ventilation (χ2=104.657, p<0.001), blood transfusion (χ2=117.649, p<0.001), and tracheal intubation (χ2=67.752, p<0.001) between CHD patients with prolonged and non-prolonged hospital stay. Multivariate logistic regression analysis showed that male (odds ratio(OR): 2.137, 95% confidence interval(CI): 1.278-3.574, p=0.004), compound types CHD (OR: 2.021, 95% CI: 1.178-3.469, p=0.011), pulmonary hypertension (OR: 3.179, 95% CI: 1.537-6.572, p=0.002), invasive mechanical ventilation (OR: 4.069, 95% CI: 1.567-10.564, p=0.004), and blood transfusion (OR: 5.128, 95% CI: 2.421-10.862, p<0.001) were independently associated with prolonged hospital stay.

Conclusion: Male, compound types CHD, pulmonary hypertension, invasive mechanical ventilation, and blood transfusion were independently associated with prolonged hospital stay in CHD patients. It provides valuable information to guide the hospitalization management of CHD.

影响左向右分流先天性心脏病儿童和青少年手术治疗延长住院时间的因素:来自中国南方某医院的证据
背景:先天性心脏病(Congenital heart disease, CHD)是由心脏和大血管发育异常引起的先天性畸形,其中左向右分流是较为常见的一种。手术治疗存在冠心病患者住院时间延长的问题。探讨儿童青少年左-右分流型冠心病术后延长住院时间的影响因素具有重要意义。方法:回顾性分析463例左向右分流型冠心病患儿及青少年手术治疗的临床资料。收集患者的医疗记录(性别、冠心病类型、超声心动图、有创机械通气、输血、气管插管、术中出血量、住院时间)。延长住院时间的阈值是根据所有患者住院时间的第三个四分位数(第75百分位数)来定义的。分析临床特征与延长住院时间的关系。结果:平均住院时间为13.00(7.00,18.00)天,其中非延长住院时间(2=67.959,p2=14.171, p=0.002)、肺动脉高压(χ2=49.611, p2=104.657, p2=117.649, p2=67.752, p=0.004)、复合型冠心病(OR: 2.021, 95% CI: 1.178 ~ 3.469, p=0.011)、肺动脉高压(OR: 3.179, 95% CI: 1.537 ~ 6.572, p=0.002)、有创机械通气(OR: 4.069, 95% CI: 1.567 ~ 10.564, p=0.004)、输血(OR: 5.128, 95% CI: 1.567 ~ 10.564, p=0.004)患者330例(71.3%)。结论:男性、复合型冠心病、肺动脉高压、有创机械通气、输血与冠心病患者住院时间延长独立相关。为指导冠心病住院管理提供了有价值的信息。
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来源期刊
Therapeutics and Clinical Risk Management
Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-
CiteScore
5.30
自引率
3.60%
发文量
139
审稿时长
16 weeks
期刊介绍: Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.
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