Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions.

IF 13.4 1区医学 Q1 CLINICAL NEUROLOGY

Neuro-oncology Pub Date : 2025-08-13 DOI:10.1093/neuonc/noaf177

Patrick Y Wen, Michael Weller, Eudocia Q Lee, Mehdi Touat, Mustafa Khasraw, Rifaquat Rahman, Michael Platten, Michael Lim, Frank Winkler, Craig Horbinski, Roel G W Verhaak, Raymond Y Huang, Manmeet S Ahluwalia, Nathalie L Albert, Joerg-Christian Tonn, David Schiff, Jill S Barnholtz-Sloan, Quinn Ostrom, Kenneth D Aldape, Tracy T Batchelor, Ranjit S Bindra, E Antonio Chiocca, Timothy F Cloughesy, John F DeGroot, Pim French, Evanthia Galanis, Norbert Galldiks, Mark R Gilbert, Monika E Hegi, Andrew B Lassman, Emilie Le Rhun, Minesh P Mehta, Ingo K Mellinghoff, Giuseppe Minniti, Patrick Roth, Marc Sanson, Martin J B Taphoorn, Andreas von Deimling, Tobias Weiss, Wolfgang Wick, Gelareh Zadeh, David A Reardon, Susan M Chang, Susan C Short, Martin J van den Bent, Matthias Preusser

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引用次数: 0

Abstract

Glioblastoma is the most common type of malignant primary brain tumor and a major cause of morbidity and mortality. In 2021 the World Health Organization updated the classification of Central Nervous System (CNS) tumors to restrict glioblastomas to isocitrate dehydrogenase-wildtype (IDHwt) tumors, improving understanding of the prognosis and optimal therapy for these tumors. This revision also enables more homogeneous populations of patients to be enrolled into clinical trials, facilitating the evaluation of novel therapies. In this updated consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of patients with glioblastoma is discussed. In addition, novel therapies such as immunotherapies, viral therapies, targeted molecular therapies, theranostics and antibody-drug conjugates will be reviewed, as well as the current challenges and future directions for research.

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成人胶质母细胞瘤：神经肿瘤学会（SNO）和欧洲神经肿瘤学会（EANO）关于当前管理和未来方向的共识综述。

胶质母细胞瘤是最常见的恶性原发性脑肿瘤，也是发病率和死亡率的主要原因。2021年，世界卫生组织更新了中枢神经系统（CNS）肿瘤的分类，将胶质母细胞瘤限制为异柠檬酸脱氢酶野生型（IDHwt）肿瘤，提高了对这些肿瘤的预后和最佳治疗方法的认识。这一修订也使得更多同质的患者被纳入临床试验，促进了新疗法的评估。在这篇来自神经肿瘤学会（SNO）和欧洲神经肿瘤协会（EANO）的最新共识综述中，讨论了胶质母细胞瘤患者的当前管理。此外，还将对免疫疗法、病毒疗法、靶向分子疗法、治疗学和抗体-药物偶联物等新疗法进行综述，以及当前面临的挑战和未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro-oncology 医学-临床神经学

CiteScore

27.20

自引率

6.30%

发文量

1434

审稿时长

3-8 weeks

期刊介绍： Neuro-Oncology, the official journal of the Society for Neuro-Oncology, has been published monthly since January 2010. Affiliated with the Japan Society for Neuro-Oncology and the European Association of Neuro-Oncology, it is a global leader in the field. The journal is committed to swiftly disseminating high-quality information across all areas of neuro-oncology. It features peer-reviewed articles, reviews, symposia on various topics, abstracts from annual meetings, and updates from neuro-oncology societies worldwide.