The Role of p53-Mediated Cellular Senescence in Idiopathic Pulmonary Fibrosis.

IF 5.2 2区医学 Q1 PHYSIOLOGY

Comprehensive Physiology Pub Date : 2025-08-01 DOI:10.1002/cph4.70041

Yueyuan Jin, Mengna Jiang, Wenxia Bu, Yifan Zhou, Juan Tang, Shan Bao, Rui Zhao, Xinyuan Zhao, Demin Cheng

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引用次数: 0

Abstract

An increasing body of evidence suggests that cellular senescence is a risk factor for the development of idiopathic pulmonary fibrosis (IPF). Cellular senescence is a permanent state by which cells cease to divide and adopt an irreversible cell cycle arrest, which is believed to contribute to aging and aging-related diseases. IPF is an age-related, chronic, progressive, and ultimately fatal interstitial lung disease of unknown etiology. IPF is characterized by repeated alveolar epithelial cell damage, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, impaired gas exchange, and death. As an important transcription factor, p53 is critically involved in the regulation of senescence and fibrosis-related diseases. The mechanism of p53-mediated cellular senescence in IPF remains poorly understood, particularly regarding therapeutic strategies targeting p53. In this review, we summarize p53's structure, function, and signaling in senescence-driven IPF, and explore p53-targeted interventions for IPF. In conclusion, p53 may be a potential therapeutic target for senescence and IPF.

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p53介导的细胞衰老在特发性肺纤维化中的作用。

越来越多的证据表明，细胞衰老是特发性肺纤维化（IPF）发展的危险因素。细胞衰老是细胞停止分裂并采取不可逆转的细胞周期停滞的一种永久状态，被认为是导致衰老和衰老相关疾病的原因。IPF是一种病因不明的年龄相关性慢性进行性最终致死性间质性肺疾病。IPF的特征是肺泡上皮细胞反复损伤、成纤维细胞增殖、细胞外基质（ECM）过度沉积、气体交换受损和死亡。作为一种重要的转录因子，p53在衰老和纤维化相关疾病的调控中起着至关重要的作用。IPF中p53介导的细胞衰老机制仍然知之甚少，特别是针对p53的治疗策略。在这篇综述中，我们总结了p53的结构、功能和信号在衰老驱动的IPF中的作用，并探讨了p53靶向干预IPF的方法。总之，p53可能是治疗衰老和IPF的潜在靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Comprehensive Physiology PHYSIOLOGY-

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.