Aenne S von Falkenhausen, Christina Krewitz, Raphaela Winter, Anna Kern, Dorothee Brunner, Stefan Brunner, Moritz F Sinner
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引用次数: 0
Abstract
Introduction: The cardiovascular effects of acute alcohol exposure remain incompletely understood, despite its reported association with arrhythmias like atrial fibrillation (AF). The Munich-BREW II study supported a link between excessive alcohol consumption, elevated heart rate, impaired heart rate variability (HRV), and increased arrhythmia incidence. Here, we present sub-analyses exploring how the amount of congested alcohol during binge drinking and the maximum breath alcohol concentration (BAC) influence these findings.
Methods: The Munich-BREW II study is a prospective, single-center cohort study conducted at LMU University Hospital, Munich between October 2016 and July 2017. Participants consumed alcohol under supervision, with hourly BAC measurements and continuous 3-lead Holter monitoring for ECG analyses of heart rate, HRV, and arrhythmias. Subgroup analyses stratified participants by quartiles of alcohol consumption and peak BAC, respectively.
Results: We analyzed 193 participants (mean age 29.9 ± 10.6 years, 36% women). Subgroup analyses revealed that higher alcohol intake during binge drinking correlated with significantly elevated heart rate (p < 0.001) and suppressed HRV measures (SDNN, p = 0.003; RMSSD, p = 0.001). Similarly, higher BAC levels were associated with increased heart rates (p < 0.001) and both reduced SDNN (p < 0.001) and RMSSD (p = 0.002). Both subgroups indicated a more pronounced effect in the highest quartile. Clinically relevant arrhythmias were not differentially distributed across subgroups.
Discussion: In this subgroup analysis of the Munich-BREW II study, higher alcohol intake and BAC during binge drinking were associated with increased heart rate and suppressed cardiac autonomic tone. The results suggest a dose response relation and discourages excessive alcohol use. Further research will need to investigate the degree of alcohol exposure to modify clinical outcomes.
期刊介绍：
Clinical Research in Cardiology is an international journal for clinical cardiovascular research. It provides a forum for original and review articles as well as critical perspective articles. Articles are only accepted if they meet stringent scientific standards and have undergone peer review. The journal regularly receives articles from the field of clinical cardiology, angiology, as well as heart and vascular surgery.
As the official journal of the German Cardiac Society, it gives a current and competent survey on the diagnosis and therapy of heart and vascular diseases.
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