The Associations of Dietary Copper and Magnesium Intake, Geriatric Nutritional Risk Index, and Systemic Inflammation Response Index with Stroke Risk in the Elderly

IF 3.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Balkan Medical Journal Pub Date : 2025-09-01 Epub Date: 2025-08-19 DOI:10.4274/balkanmedj.galenos.2025.2025-7-25
Baochun Luo, Sifan Liu, Lei Zheng, Baiwen Zhang, Wei Zou
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Abstract

Background: The effects of dietary copper and magnesium intake, the geriatric nutritional risk index (GNRI), and the systemic inflammation response index (SIRI) on stroke risk in the elderly remain unclear.

Aims: To examine the relationships between dietary copper and magnesium intake, GNRI, SIRI, and stroke risk in the elderly.

Study design: Cross-sectional study.

Methods: Data from 7,157 elderly participants in National Health and Nutrition Examination Survey 2007-2016 were analyzed using multifactorial logistic regression, subgroup analysis, smooth curve fitting, threshold effect analysis, mediation analysis, and sensitivity analysis.

Results: Higher dietary copper and magnesium intake were significantly and linearly associated with lower stroke risk. SIRI was positively associated with stroke risk, while GNRI had a stable protective effect. In fully adjusted models, medium- and high-level copper and magnesium intake were positively associated with GNRI and negatively associated with SIRI. GNRI mediated 4.4% and 5.5% of the associations between copper and magnesium intake and stroke risk, respectively; SIRI mediated 3.4% and 2.9%, respectively.

Conclusion: Higher dietary copper and magnesium intake are associated with reduced stroke risk in the elderly, with GNRI and SIRI exerting modest mediating effects.

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膳食铜镁摄入量、老年营养风险指数和全身炎症反应指数与老年人卒中风险的关系
背景:膳食铜和镁摄入量、老年营养风险指数(GNRI)和全身炎症反应指数(SIRI)对老年人脑卒中风险的影响尚不清楚。目的:研究老年人膳食铜和镁摄入量、GNRI、SIRI和中风风险之间的关系。研究设计:横断面研究。方法:采用多因素logistic回归、亚组分析、平滑曲线拟合、阈值效应分析、中介分析和敏感性分析等方法,对2007-2016年全国健康与营养调查7157名老年人的数据进行分析。结果:较高的膳食铜和镁摄入量与较低的卒中风险显著线性相关。SIRI与中风风险呈正相关,而GNRI具有稳定的保护作用。在完全调整的模型中,中等和高水平的铜和镁摄入量与GNRI呈正相关,与SIRI负相关。GNRI分别介导了4.4%和5.5%的铜和镁摄入量与中风风险之间的关联;SIRI分别介导3.4%和2.9%。结论:较高的膳食铜和镁摄入量与老年人卒中风险降低相关,GNRI和SIRI发挥适度的中介作用。
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来源期刊
Balkan Medical Journal
Balkan Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
4.10
自引率
6.70%
发文量
76
审稿时长
6-12 weeks
期刊介绍: The Balkan Medical Journal (Balkan Med J) is a peer-reviewed open-access international journal that publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports and clinical images, invited reviews, editorials, letters, comments and letters to the Editor including reports on publication and research ethics. The journal is the official scientific publication of the Trakya University Faculty of Medicine, Edirne, Turkey and is printed six times a year, in January, March, May, July, September and November. The language of the journal is English. The journal is based on independent and unbiased double-blinded peer-reviewed principles. Only unpublished papers that are not under review for publication elsewhere can be submitted. Balkan Medical Journal does not accept multiple submission and duplicate submission even though the previous one was published in a different language. The authors are responsible for the scientific content of the material to be published. The Balkan Medical Journal reserves the right to request any research materials on which the paper is based. The Balkan Medical Journal encourages and enables academicians, researchers, specialists and primary care physicians of Balkan countries to publish their valuable research in all branches of medicine. The primary aim of the journal is to publish original articles with high scientific and ethical quality and serve as a good example of medical publications in the Balkans as well as in the World.
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