Opportunities for automation in continuous dynamic flow separation

IF 3.1 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Reaction Chemistry & Engineering Pub Date : 2025-07-15 DOI:10.1039/D5RE00215J

Chetsada Khositanon, Panitan Thakhiew, Charoen Chinwanitcharoen, Kousuke Hiromori and Nopphon Weeranoppanant

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Abstract

Many separation techniques, such as chromatography, adsorption, and filtration, are dynamic by nature, with the profiles of chemical species varying over time. This time-dependent behavior makes dynamic flow separation inherently batchwise. Recently, automation has enabled the transformation of these batchwise processes into continuous operations. Automation devices, including separators, detectors/transmitters, control systems, and control devices, can be implemented for either open-loop or closed-loop control. In this minireview, we provide an overview of recent technologies for automated dynamic flow separation systems. Major automated separation techniques, such as liquid–liquid extraction, counter-current chromatography, flash chromatography, and dead-end filtration, are highlighted to illustrate how automation facilitates their transition to continuous operation. Additional examples of integrated reaction–separation systems and self-optimizing platforms for identifying optimal separation conditions are presented as part of the outlook for automated setups. Challenges related to accurate in-line detection, complex sample matrices, and varying physical properties are also addressed.

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在连续动态流动分离中实现自动化的机会

许多分离技术，如色谱、吸附和过滤，本质上是动态的，化学物质的特征随时间而变化。这种与时间相关的行为使得动态流动分离本质上是分批的。最近，自动化使这些批处理过程转变为连续操作成为可能。自动化设备，包括分离器，检测器/变送器，控制系统和控制设备，可以实现开环或闭环控制。在这篇小型综述中，我们概述了自动化动态流动分离系统的最新技术。主要的自动化分离技术，如液-液萃取、逆流色谱、闪蒸色谱和终端过滤，重点介绍了自动化如何促进它们向连续操作的过渡。作为自动化装置展望的一部分，介绍了用于识别最佳分离条件的集成反应分离系统和自优化平台的其他示例。与准确的在线检测、复杂的样品矩阵和不同的物理性质相关的挑战也得到了解决。

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来源期刊

Reaction Chemistry & Engineering Chemistry-Chemistry (miscellaneous)

CiteScore

6.60

自引率

7.70%

发文量

227

期刊介绍： Reaction Chemistry & Engineering is a new journal reporting cutting edge research into all aspects of making molecules for the benefit of fundamental research, applied processes and wider society. From fundamental, molecular-level chemistry to large scale chemical production, Reaction Chemistry & Engineering brings together communities of chemists and chemical engineers working to ensure the crucial role of reaction chemistry in today’s world.