TUCUXI-Core: An Open Source generic and efficient computing engine for Model-Informed Precision Dosing

Abstract

The absorption, distribution, metabolism, and excretion of drugs vary from one individual to another. As a result, drug concentration profiles in the blood do not evolve in the same way throughout the population. Measuring drug concentrations and individualizing drug dosages therefore makes it possible to respond to the specific needs of patients, so that their circulating exposure to the drug reaches targets that are both effective in achieving treatment objectives and safe regarding potential toxicity.

In this context, software tools can usefully assist prescribers in the process of adjusting drug dosages based on the therapeutic monitoring of blood concentrations, which is increasingly available in clinical laboratories. Bayesian adaptation based on prior population pharmacokinetic knowledge is the gold standard strategy for this. This article presents the core computing engine of TUCUXI, a software package that aims to support clinicians in this activity through a user-friendly graphical interface. We describe its main features and architecture, providing a general overview of this open-source project.