Potentiation of GPCR signaling by ATP and sugar monophosphates.

IF 19.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2025-10-01 Epub Date: 2025-08-15 DOI:10.1016/j.tips.2025.08.002

Sam R J Hoare

引用次数: 0

Abstract

Allosteric potentiation of G protein-coupled receptor (GPCR) signaling provides new opportunities for therapeutic discovery. Recently, the laboratory of Peter Chidiac has reported strong allosteric potentiation of numerous GPCRs by extracellular ATP, with the minimal pharmacophore represented by sugar monophosphates. This discovery potentially aids the development of novel allosteric modulators for numerous therapeutically attractive GPCRs.

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ATP和单磷酸糖对GPCR信号的增强作用。

G蛋白偶联受体（GPCR）信号的变构增强为治疗发现提供了新的机会。最近，Peter Chidiac实验室报道了细胞外ATP对许多gpcr的强变构增强作用，其中以单磷酸糖为代表的药效团最小。这一发现可能有助于开发许多具有治疗吸引力的gpcr的新型变构调节剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.