CALD1-derived circ-0003746 targeting miR-526b promotes EMT-mediated bladder cancer progression

IF 3.5 3区 生物学 Q3 CELL BIOLOGY
Dengke Yang , Weipu Mao , Lei Jiang , Bingyan Liu , Jiang Geng
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引用次数: 0

Abstract

CALD1 is critical to bladder cancer (BCa) development. Circ-0003746 is a circRNA derived from two exons of CALD1. However, the functional role of circ-0003746 in BCa remains inadequately explored. This study investigated its involvement in BCa. Circ-0003746 was found to be overexpressed in BCa tissues and cell lines. Silencing circ-0003746 suppressed both proliferation and migration of BCa cells in vitro and in vivo. miR-526b was identified as a potential target of circ-0003746. Luciferase reporter assays confirmed the interaction between circ-0003746 and miR-526b. Mechanistically, circ-0003746 promotes epithelial-mesenchymal transition (EMT) by sequestering miR-526b, thereby advancing BCa progression. These findings highlight the role of circ-0003746 in regulating the miR-526b/EMT axis, positioning it as a potential biomarker for BCa.
cald1衍生的circ-0003746靶向miR-526b促进emt介导的膀胱癌进展。
CALD1对膀胱癌(BCa)的发展至关重要。Circ-0003746是源自CALD1的两个外显子的circRNA。然而,circ-0003746在BCa中的功能作用仍未得到充分探讨。本研究探讨了其在BCa中的作用。Circ-0003746在BCa组织和细胞系中过表达。circ-0003746的沉默抑制了BCa细胞在体外和体内的增殖和迁移。miR-526b被认为是circ-0003746的潜在靶标。荧光素酶报告基因检测证实circ-0003746与miR-526b之间存在相互作用。在机制上,circ-0003746通过隔离miR-526b促进上皮-间质转化(EMT),从而促进BCa进展。这些发现强调了circ-0003746在调节miR-526b/EMT轴中的作用,将其定位为BCa的潜在生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Experimental cell research
Experimental cell research 医学-细胞生物学
CiteScore
7.20
自引率
0.00%
发文量
295
审稿时长
30 days
期刊介绍: Our scope includes but is not limited to areas such as: Chromosome biology; Chromatin and epigenetics; DNA repair; Gene regulation; Nuclear import-export; RNA processing; Non-coding RNAs; Organelle biology; The cytoskeleton; Intracellular trafficking; Cell-cell and cell-matrix interactions; Cell motility and migration; Cell proliferation; Cellular differentiation; Signal transduction; Programmed cell death.
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