BMP Signaling Alleviates Allergic Airway Inflammation by Controlling Group 2 Innate Lymphoid Cells Homeostasis

IF 3.7 3区 医学 Q2 IMMUNOLOGY
Shan Yue, Huihui Li, Zhiqiang Yan, Mengying Xie, Mengyuan Dai, Mingying Zhang, Wei Xu
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Abstract

Recent studies have highlighted the important role of bone morphogenetic proteins (BMPs) in immunoregulation. Our earlier work identified the expression of BMP receptors on lymphoid progenitors and group 2 innate lymphoid cells (ILC2s) in the bone marrow. However, the precise function of BMP signaling in the development and activity of ILC2s remains unclear. This study aimed to investigate whether BMP signaling regulates the generation of ILC2s and their effector functions during lung airway inflammation. We generated BMP receptor 2 (BMPR2) conditional knockout (CKO) mice to analyze ILC2 development and function. We found that BMPR2 deficiency led to an increased number of ILC2s in the lung at steady state, primarily due to enhanced cell proliferation. This expansion resulted in aggravation of early type 2 response in a papain-induced allergic airway inflammation model. BMP4 restrained the proliferation of ILC2s in vitro and in vivo through activation of the canonical BMP signaling pathway. Administration of BMP4 alleviated papain-induced airway inflammation in control mice, whereas this therapeutic effect was abolished in BMPR2 conditional knockout mice. In conclusion, our study demonstrated that BMP signaling regulates allergic airway inflammation by controlling ILC2s homeostasis.

Abstract Image

BMP信号通过控制2组先天淋巴样细胞稳态减轻过敏性气道炎症
最近的研究强调了骨形态发生蛋白(BMPs)在免疫调节中的重要作用。我们早期的工作发现BMP受体在骨髓淋巴样祖细胞和2组先天淋巴样细胞(ILC2s)上的表达。然而,BMP信号在ILC2s的发育和活性中的确切功能尚不清楚。本研究旨在探讨肺气道炎症过程中BMP信号是否调控ILC2s的产生及其效应功能。我们生成BMP受体2 (BMPR2)条件敲除(CKO)小鼠来分析ILC2的发育和功能。我们发现,BMPR2缺乏导致肺稳态ILC2s数量增加,主要是由于细胞增殖增强。在木瓜蛋白酶诱导的过敏性气道炎症模型中,这种扩张导致早期2型反应加重。BMP4通过激活典型的BMP信号通路,在体外和体内抑制ILC2s的增殖。在对照组小鼠中,给药BMP4减轻了木瓜蛋白酶诱导的气道炎症,而在BMPR2条件敲除小鼠中,这种治疗作用被消除。总之,我们的研究表明BMP信号通过控制ILC2s的稳态来调节过敏性气道炎症。
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来源期刊
CiteScore
8.30
自引率
3.70%
发文量
224
审稿时长
2 months
期刊介绍: The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.
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