Copper-Catalyzed Synthesis of Pyrazolo[4′,5′:4,5]Pyrimido[1,2-c]Quinazolines via Ullmann, Decarboxylation and Oxidative Coupled Dehydrogenation

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2025-07-06 DOI:10.1002/jhet.70010

Yun-Xiang Zhou, Lu-Yi Wang, Wei-Dong Jiang, Lai-Long Mu, Lan-Lan Lv, Xiang-Shan Wang

引用次数: 0

Abstract

5-(2-Bromophenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d] pyrimidin-7-one was used as a reactant to react with l-proline or pipecolic acid catalyzed by CuI, and it underwent consecutive Ullmann coupling, decarboxylation, and oxidative coupled dehydrogenation to give pyrazolo[4′,3′:4,5] pyrimido[1,2-c] pyrrolo/pyrido [1,2-a]quinazolin-13(12H)-ones in good yields.

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铜催化乌尔曼、脱羧和氧化偶联脱氢合成吡唑啉[4′，5′：4,5]嘧啶[1,2-c]喹唑啉

以5-（2-溴苯基）-1-甲基-3-丙基-1,6-二氢- 7h -吡唑啉[4,3-]嘧啶-7- 1为反应物，在CuI催化下与l-脯氨酸或辣椒酸反应，经过Ullmann偶联、脱羧、氧化偶联脱氢，得到吡唑啉[4′，3′：4,5]嘧啶[1,2-c]吡咯/吡唑啉[1,2-a]喹唑啉-13(12H)- 1，产率较高。

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.