Visible Light Mediated One Pot Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazole

Abstract

A one-pot, three-component photo redox process has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives under mild conditions using a catalytic amount of photocatalyst. The method involves the visible light-mediated coupling of isothiocyanates with hydrazines, followed by intramolecular cyclization with the aid of an alkyl halide to form the desired substituted oxadiazole molecule. The method has been optimized for a wide range of substrates and produces moderate to good yields. The simplicity and efficiency of this method make it a useful tool for the synthesis of structurally interesting molecules for various applications.