A novel early imaging biomarker for glymphatic function: Cerebral cortical arterial pulsatility index from 2-Minute phase-contrast MRI.

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The Journal of Prevention of Alzheimer's Disease Pub Date : 2025-11-01 Epub Date: 2025-08-14 DOI:10.1016/j.tjpad.2025.100323

Sung-Hye You, Byungjun Kim, Moonjung Hwang, Kyung-Sook Yang, Hye-Won Park, InSeong Kim, SuGil Kim, Kyung Min Kim, Bo Kyu Kim, Jae Ho Shin

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Abstract

Background: Arterial pulsatility is one of the driving forces of glymphatic flow.

Objectives: To evaluate the feasibility of the pulsatility index (PI) of cortical arteries in the centrum semiovale (PI_CSO) as a novel non-invasive imaging biomarker for Alzheimer's disease (AD) in the context of glymphatic function.

Design: Retrospective cross-sectional study.

Setting: Single tertiary academic center equipped with both 3.0 T MRI systems.

Participants: A total of 160 individuals were enrolled: 50 healthy volunteers, 46 cognitively normal controls, and 64 AD patients who underwent diffusion tensor imaging (DTI) and 2D phase-contrast MRI.

Measurements: Diffusion Tensor Imaging Analysis along the Perivascular Space (DTI-ALPS) index and PI_CSO were assessed using 2D phase-contrast MRI. Correlations with age, DTI-ALPS index, and Mini-Mental State Examination (MMSE) scores were analyzed.

Results: PI_CSO was significantly higher in the AD group than those in healthy volunteers (P<0.001) and cognitively normal aging (P=0.001) groups. PI_CSO correlated positively with age (rho=0.613, P<0.001) and negatively with both the DTI-ALPS index (rho=-0.439, P<0.001) and MMSE scores (rho=-0.486, P<0.001) in total group.

Conclusion: PI_CSO derived from 2D phase-contrast 3.0T MRI may serve as a novel imaging biomarker for Alzheimer's disease in relation to glymphatic function.

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一种新的淋巴功能早期成像生物标志物：2分钟相衬MRI的大脑皮质动脉搏动指数。

背景：动脉搏动是淋巴血流的动力之一。目的：评价半瓣膜中心（PICSO）皮质动脉脉搏指数（PI）在淋巴功能方面作为阿尔茨海默病（AD）一种新的无创成像生物标志物的可行性。设计：回顾性横断面研究。设置：单个三级学术中心，配备两台3.0 T MRI系统。参与者：共纳入160人：50名健康志愿者，46名认知正常对照，64名AD患者接受弥散张量成像（DTI）和二维相位对比MRI。测量方法：采用二维相衬MRI评估沿血管周围间隙扩散张量成像分析（DTI-ALPS）指数和PICSO。分析其与年龄、DTI-ALPS指数和简易精神状态检查（MMSE）评分的相关性。结果：AD组的PICSO明显高于健康志愿者(PCSO与年龄呈正相关（rho=0.613, p）。结论：2D相对比3.0T MRI获得的PICSO可能作为一种新的与淋巴功能相关的阿尔茨海默病成像生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health

CiteScore

9.20

自引率

0.00%

发文量

期刊介绍： The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.