Exploring PTX3: a promising diagnostic marker and therapeutic target in neurology

IF 2.4 3区生物学 Q2 GENETICS & HEREDITY

Gene Pub Date : 2025-08-13 DOI:10.1016/j.gene.2025.149724

Hong Peng , Lu Zhang , Yufen Tang , Peng Huang , Senlin Luo , Zhou She , Yuqiong Chen , Jinwen Luo , Wangxin Duan , Lingjuan Liu , Xingfang Li , Liqun Liu

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引用次数: 0

Abstract

Pentraxin 3 (PTX3), a key member of the pentraxin (PTX) family, is a highly conserved, multifunctional soluble humoral pattern recognition molecule. It plays a pivotal regulatory role in innate immunity, infection-inflammation, tissue remodeling, and tumorigenesis. Recent research has revealed a close association between PTX3 and the pathogenesis and progression of neurological diseases. This review details the gene localization, protein domains, and high-resolution three-dimensional conformation of PTX3. It systematically explores its core functions within signaling pathways of neurological disorders, including its regulation of synaptic plasticity and neurotransmission, involvement in neuroinflammation and immune homeostasis, promotion of nervous system tumorigenesis and progression, and mediation of fibrosis and tissue repair. Furthermore, the review evaluates the clinical value of PTX3 as a potential diagnostic and prognostic biomarker for various neurological conditions (e.g., stroke, neurodegenerative diseases, central nervous system infections, gliomas, multiple sclerosis, neurotrauma, neuropsychiatric disorders, and epilepsy). It summarizes the correlation between alterations in PTX3 expression levels in bodily fluids and tissues and disease activity, severity, and prognosis. The review also discusses the therapeutic prospects of targeting PTX3, encompassing both PTX3 inhibitors and recombinant PTX3. Overall, this review aims to comprehensively delineate the multifaceted roles of PTX3 in neurological diseases, highlighting its significant potential as both a biomarker and therapeutic target. It thus provides important opportunities for developing PTX3-based diagnostic tools and innovative therapies to improve the clinical management of diverse neurological disorders.

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探索PTX3：一个有前途的神经病学诊断标志物和治疗靶点。

戊traxin 3 （PTX3）是戊traxin （PTX）家族的关键成员，是一种高度保守的多功能可溶性体液模式识别分子。它在先天免疫、感染-炎症、组织重塑和肿瘤发生中起着关键的调节作用。最近的研究表明PTX3与神经系统疾病的发病和进展密切相关。本文详细介绍了PTX3的基因定位、蛋白结构域和高分辨率三维构象。系统探讨其在神经系统疾病信号通路中的核心功能，包括调节突触可塑性和神经传递，参与神经炎症和免疫稳态，促进神经系统肿瘤发生和进展，介导纤维化和组织修复。此外，该综述评估了PTX3作为各种神经系统疾病（如中风、神经退行性疾病、中枢神经系统感染、胶质瘤、多发性硬化症、神经创伤、神经精神疾病和癫痫）的潜在诊断和预后生物标志物的临床价值。它总结了体液和组织中PTX3表达水平的改变与疾病活动、严重程度和预后之间的相关性。本文还讨论了靶向PTX3的治疗前景，包括PTX3抑制剂和重组PTX3。总之，本综述旨在全面描述PTX3在神经系统疾病中的多方面作用，强调其作为生物标志物和治疗靶点的巨大潜力。因此，它为开发基于ptx3的诊断工具和创新疗法提供了重要机会，以改善各种神经系统疾病的临床管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene 生物-遗传学

CiteScore

6.10

自引率

2.90%

发文量

718

审稿时长

42 days

期刊介绍： Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.