CircRNAs: functions and emerging roles in cancer and immunotherapy.

IF 8.3 1区医学 Q1 MEDICINE, GENERAL & INTERNAL

BMC Medicine Pub Date : 2025-08-15 DOI:10.1186/s12916-025-04306-5

Yan Wang, Yanru Cui, Xin Li, Su-Han Jin, Haitao Wang, Udo S Gaipl, Hu Ma, Shixiang Wang, Jian-Guo Zhou

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引用次数: 0

Abstract

Background: Circular RNAs (circRNAs) are emerging as promising tools in cancer and immunotherapy, with unique characteristics that offer potential therapeutic applications.

Main body: This review outlines the discovery, biogenesis, and mechanisms of circRNAs, emphasizing their roles in cancer and immune regulation. CircRNAs modulate immune responses by acting as miRNA sponges, binding RNA-binding proteins, or serving as translation templates. These interactions influence T cells, NK cells, macrophages, and immune checkpoints. The review also explores circRNAs' roles in different cancers, focusing on target identification, immune effects, and mechanisms of action. Additionally, it examines circRNA-based therapies, including vaccines, CAR-T cell therapy, and database applications.

Conclusion: Despite their potential, technical hurdles must be overcome to advance circRNAs' clinical use in cancer immunotherapy. Future research should focus on addressing these challenges to fully realize the therapeutic potential of circRNAs.

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环状rna：在癌症和免疫治疗中的功能和新角色。

背景：环状rna （circRNAs）正在成为癌症和免疫治疗中有前景的工具，其独特的特性提供了潜在的治疗应用。正文：本文综述了环状rna的发现、生物发生和机制，重点介绍了它们在癌症和免疫调节中的作用。CircRNAs通过作为miRNA海绵、结合rna结合蛋白或作为翻译模板来调节免疫反应。这些相互作用影响T细胞、NK细胞、巨噬细胞和免疫检查点。这篇综述还探讨了circRNAs在不同癌症中的作用，重点是靶标识别、免疫效应和作用机制。此外，它还检查基于circrna的疗法，包括疫苗、CAR-T细胞疗法和数据库应用。结论：尽管具有潜力，但要推进circrna在癌症免疫治疗中的临床应用，必须克服技术障碍。未来的研究应着眼于解决这些挑战，以充分发挥circrna的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medicine 医学-医学：内科

CiteScore

13.10

自引率

1.10%

发文量

435

审稿时长

4-8 weeks

期刊介绍： BMC Medicine is an open access, transparent peer-reviewed general medical journal. It is the flagship journal of the BMC series and publishes outstanding and influential research in various areas including clinical practice, translational medicine, medical and health advances, public health, global health, policy, and general topics of interest to the biomedical and sociomedical professional communities. In addition to research articles, the journal also publishes stimulating debates, reviews, unique forum articles, and concise tutorials. All articles published in BMC Medicine are included in various databases such as Biological Abstracts, BIOSIS, CAS, Citebase, Current contents, DOAJ, Embase, MEDLINE, PubMed, Science Citation Index Expanded, OAIster, SCImago, Scopus, SOCOLAR, and Zetoc.