Weight gain in infancy and metabolic dysfunction-associated steatotic liver disease (MASLD) in a prospective birth cohort of Latino children.

Maternal health, neonatology and perinatology Pub Date : 2025-08-15 DOI:10.1186/s40748-025-00225-8

Sarah L Maxwell, Jennifer C Price, Emily R Perito, Philip Rosenthal, Janet M Wojcicki

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Abstract

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease among U.S. children. Early weight trajectories correlate with obesity, cardiometabolic syndrome, and MASLD in children born small for gestational age.

Methods: We evaluated whether increases in weight-for-age (WAZ) score from 0 to 6 months of life, are associated with MASLD in middle childhood, in two prospective birth cohorts of healthy Latino children (n = 136).

Results: After adjusting for confounders, increases in WAZ score from 0 to 6 months of age were associated with a higher risk for MASLD in middle childhood (OR 1.54 95% CI, 1.01-2.36; p = 0.046).

Conclusions: In a prospective study of Latino children, increases in WAZ score from 0 to 6 months were associated with increased risk of MASLD in mid-childhood. This could inform early screening and counseling for MASLD.

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婴儿期体重增加和代谢功能障碍相关的脂肪变性肝病（MASLD）在一项前瞻性拉丁裔儿童出生队列中的研究

背景：代谢功能障碍相关脂肪变性肝病（MASLD）是美国儿童中最常见的慢性肝病。出生时胎龄小的儿童早期体重轨迹与肥胖、心脏代谢综合征和MASLD相关。方法：我们在两组健康拉丁裔儿童（n = 136）的前瞻性出生队列中评估了0 - 6个月出生时体重年龄比（WAZ）评分的增加是否与儿童中期MASLD相关。结果：调整混杂因素后，0 ~ 6月龄WAZ评分的增加与儿童中期MASLD的高风险相关(OR 1.54 95% CI, 1.01-2.36；p = 0.046)。结论：在一项针对拉丁裔儿童的前瞻性研究中，从0到6个月WAZ评分的增加与儿童中期MASLD的风险增加有关。这可以为MASLD的早期筛查和咨询提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Maternal health, neonatology and perinatology

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12 weeks