Experimental analysis of blast shock wave-induced injuries in rats: Neurobehavioral and tissue damage assessments

IF 4.2 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2025-08-12 DOI:10.1016/j.expneurol.2025.115427

Boya Yu, Hong Wang, Xiaolin Fan, Liang Li, Xiao Li, Yuhao Zhang, Jinxuan Ma, Ning Ma, Qi Wang, Qing Lu, Junhong Gao

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Abstract

To investigate the dynamic response characteristics of personnel injuries caused by blast shock waves under actual working conditions, experimental studies on blast-induced injuries in rats, behavioral experiments post-injury, and pathological examinations were conducted, followed by injury assessments. The results showed that all rats died when the peak overpressure was 0.427 MPa. At a peak overpressure of 0.192 MPa, the rats were assessed as moderately injured. Behavioral tests at 7 and 28 days revealed reduced motor ability and decreased autonomous exploration, with statistically significant results (P < 0.05). Pathological examinations indicated gradual recovery of brain and lung tissues, with only minor residual damage by day 28. At a peak overpressure of 0.125 MPa, the rats were classified as mildly injured. Statistically significant behavioral differences were observed only on day 7 (P < 0.05), and pathological results demonstrated complete recovery of brain and lung tissues by day 28. These findings provide valuable references for future personnel injury assessments and engineering applications.

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爆炸冲击波致大鼠损伤的实验分析：神经行为和组织损伤评估。

为了研究爆炸冲击波对实际工作条件下人员损伤的动态响应特性，我们进行了大鼠爆炸损伤实验研究、伤后行为实验和病理检查，并进行了损伤评估。结果表明，当超压峰值为0.427 MPa时，所有大鼠均死亡。峰值超压为0.192 MPa时，判定大鼠为中度损伤。第7天和第28 天的行为测试显示，运动能力和自主探索能力下降，结果具有统计学意义(P

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.