Iron deficiency anemia as a risk factor associated with stroke and cerebral venous thrombosis in children and adults - a systematic review

IF 3.4 3区医学 Q1 HEMATOLOGY

Thrombosis research Pub Date : 2025-08-05 DOI:10.1016/j.thromres.2025.109425

Mai Erritzøe-Jervild , Christina Kruuse , Arkadiusz Weglewski , Nina Vindegaard Sørensen

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引用次数: 0

Abstract

Objectives

Iron deficiency anemia (IDA) might have an association with stroke and cerebral venous thrombosis (CVT), but no systematic evaluation of the literature has been conducted to support this. The aim of this systematic review was to assess IDA as a potential risk factor for stroke and CVT by analyzing all papers published on IDA-related strokes and CVTs.

Methods and materials

A systematic review by use of the databases EMBASE and Pubmed. The study was registered at PROSPERO before data collection and PRISMA guidelines were followed. Case reports and studies on IDA as a risk factor for stroke and CVT were included with no limitations, though papers not written in English were excluded.

Results

In total, 2202 papers were identified of which 87 were included, hereof 71 case reports or -series, 16 observational studies, and two papers comprising both categories. The 18 observational studies indicated an association of IDA with stroke, however, were limited by sample size. The case reports included 52 adult and 53 pediatric cases. Females accounted for 65.7 % of all reported cases. The median age of all included cases was 17.0 years (range 0.4–70.0). Mean hemoglobin was 6.7 g/dL (SD 2.3), and mean ferritin was 7 ng/mL (SD 6).

Conclusion

IDA is an under-investigated potential risk factor for stroke and CVT—especially in children and younger adults. Large-scale, longitudinal studies are needed to confirm IDA as a stroke and CVT risk factor and identify specific subgroups at a higher risk of stroke and CVT associated with IDA.

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缺铁性贫血是儿童和成人中风和脑静脉血栓形成相关的危险因素——一项系统综述

目的：缺铁性贫血（IDA）可能与脑卒中和脑静脉血栓形成（CVT）有关，但尚无系统的文献评价支持这一观点。本系统综述的目的是通过分析所有与IDA相关的卒中和CVT发表的论文，评估IDA作为卒中和CVT的潜在危险因素。方法与材料采用EMBASE和Pubmed数据库进行系统综述。在数据收集和PRISMA指南遵循之前，该研究在PROSPERO注册。关于IDA作为卒中和CVT危险因素的病例报告和研究被纳入，没有限制，但非英文论文被排除在外。结果共纳入文献2202篇，其中纳入文献87篇，其中病例报告或系列71篇，观察性研究16篇，两类均纳入的文献2篇。18项观察性研究表明IDA与卒中相关，但样本量有限。病例报告包括52例成人病例和53例儿科病例。女性占所有报告病例的65.7%。所有纳入病例的中位年龄为17.0岁（范围0.4-70.0）。平均血红蛋白6.7 g/dL (SD 2.3)，平均铁蛋白7 ng/mL （SD 6）。结论ida是卒中和cvt的潜在危险因素，尤其是在儿童和年轻人中。需要大规模的纵向研究来证实IDA是卒中和CVT的危险因素，并确定与IDA相关的卒中和CVT风险较高的特定亚组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thrombosis research 医学-外周血管病

CiteScore

14.60

自引率

4.00%

发文量

364

审稿时长

31 days

期刊介绍： Thrombosis Research is an international journal dedicated to the swift dissemination of new information on thrombosis, hemostasis, and vascular biology, aimed at advancing both science and clinical care. The journal publishes peer-reviewed original research, reviews, editorials, opinions, and critiques, covering both basic and clinical studies. Priority is given to research that promises novel approaches in the diagnosis, therapy, prognosis, and prevention of thrombotic and hemorrhagic diseases.