Sleep Disruption and Atrial Fibrillation: Evidence, Mechanisms and Clinical Implications.

IF 16.2 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation research Pub Date : 2025-08-14 DOI:10.1161/circresaha.125.325612

Abhishek Deshmukh,Naima Covassin,Yves Dauvilliers,Virend K Somers

引用次数: 0

Abstract

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, with its incidence rising due to aging populations, obesity, and advancements in diagnostic modalities. The interplay between sleep disorders and AF is increasingly recognized, with obstructive sleep apnea (OSA) serving as a well-established risk factor. However, emerging evidence implicates additional sleep disturbances-including central sleep apnea, insomnia, and restless legs syndrome-in AF pathogenesis and progression. Despite compelling observational data, interventional studies evaluating the impact of sleep disorder treatment on AF outcomes have yielded mixed results. Although continuous positive airway pressure therapy in patients with OSA mitigates AF recurrence, randomized controlled trials have yet to confirm a definitive causal benefit. This review synthesizes epidemiological, mechanistic, and interventional data linking sleep disorders to AF.

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睡眠中断和心房颤动：证据、机制和临床意义。

房颤（AF）是最常见的持续性心律失常，由于人口老龄化、肥胖和诊断方式的进步，其发病率不断上升。睡眠障碍和房颤之间的相互作用越来越被认识到，阻塞性睡眠呼吸暂停（OSA）是一个公认的危险因素。然而，新出现的证据表明，额外的睡眠障碍-包括中枢性睡眠呼吸暂停，失眠和不宁腿综合征-在房颤的发病和进展中。尽管有令人信服的观察数据，但评估睡眠障碍治疗对房颤结果影响的干预性研究得出了不同的结果。尽管OSA患者持续气道正压治疗可减轻房颤复发，但随机对照试验尚未证实其明确的因果效益。本文综述了将睡眠障碍与房颤联系起来的流行病学、机制和干预数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation research 医学-外周血管病

CiteScore

29.60

自引率

2.00%

发文量

535

审稿时长

3-6 weeks

期刊介绍： Circulation Research is a peer-reviewed journal that serves as a forum for the highest quality research in basic cardiovascular biology. The journal publishes studies that utilize state-of-the-art approaches to investigate mechanisms of human disease, as well as translational and clinical research that provide fundamental insights into the basis of disease and the mechanism of therapies. Circulation Research has a broad audience that includes clinical and academic cardiologists, basic cardiovascular scientists, physiologists, cellular and molecular biologists, and cardiovascular pharmacologists. The journal aims to advance the understanding of cardiovascular biology and disease by disseminating cutting-edge research to these diverse communities. In terms of indexing, Circulation Research is included in several prominent scientific databases, including BIOSIS, CAB Abstracts, Chemical Abstracts, Current Contents, EMBASE, and MEDLINE. This ensures that the journal's articles are easily discoverable and accessible to researchers in the field. Overall, Circulation Research is a reputable publication that attracts high-quality research and provides a platform for the dissemination of important findings in basic cardiovascular biology and its translational and clinical applications.